What do systematic reviews say?

Analgesic (any: NSAID, paracetamol, local anaesthetic or opioid) vs placebo or control

The review found no eligible studies for this question.

• Pharmacological interventions for pain relief during orthodontic treatment 2017 · Cochrane All outcomes
  No studies in this comparison reported any adverse events. SoF cell: 'Not reported'.
  0 studies
  No studies found

Preoperative ibuprofen vs placebo

• Preoperative analgesics for additional pain relief in children and adolescents having dental treatment 2016 · Cochrane All outcomes
  One participant from the ibuprofen group and one from the placebo group reported a lip or cheek biting injury (Bernhardt 2001). No other adverse events were recorded for Bernhardt 2001 and Law 2000.
  2 studies
  GRADE not reported

Preoperative paracetamol (acetaminophen) vs placebo

• Preoperative analgesics for additional pain relief in children and adolescents having dental treatment 2016 · Cochrane All outcomes
  No adverse events were recorded in Primosch 1995. The other two studies did not mention adverse events.
  1 study
  GRADE not reported

Oral paracetamol vs placebo

Paracetamol (single oral dose, any dose or formulation; subgroups up… showed no clear difference in patients with one or more adverse events compared with placebo; GRADE not reported.

• Paracetamol for pain relief after surgical removal of lower wisdom teeth 2007 · Cochrane All outcomes

  up to 7 days
  RR 1.19 [0.90, 1.57]
  17 studies · 1645 participants
  GRADE not reported