Findings

What do systematic reviews say?

10 questions · 10 findings · 5 reviews · Common Mental Disorders

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No studies found 4 · 40%GRADE not reported 0 · 0%Very low 5 · 50%Low 1 · 10%Moderate 0 · 0%High 0 · 0%

Pharmacological interventions vs placebo

acceptability ‐ drop‐outs due to adverse events: post‐intervention · adults with long‐term physical conditions (18 years or older)

It is very uncertain whether pharmacological interventions changes acceptability ‐ drop‐outs due to adverse events: post‐intervention compared with placebo (very low certainty).

1 finding from 1 review

Prevention of depression in adults with long‐term physical conditions 2021 · Cochrane Headline outcomes only
OR 2.05 [1.07, 3.89]
5 studies · 561 participants
Very low

Pharmacological interventions vs placebo

Tolerability ‐ total number of adverse events · adults with long‐term physical conditions (18 years or older)

1 finding from 1 review

Prevention of depression in adults with long‐term physical conditions 2021 · Cochrane Headline outcomes only
no estimate extracted
5 studies · 5 participants
Very low

Antidepressants vs any other pharmacological intervention

Adverse events · women of any age, with PND up to 12 months

The review found no eligible studies for this question.

1 finding from 1 review

Antidepressant treatment for postnatal depression 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Selective serotonin reuptake inhibitors vs placebo

Adverse events (nausea, dizziness) · chronic obstructive pulmonary disease (COPD) with depression

1 finding from 1 review

Pharmacological interventions for the treatment of depression in chronic obstructive pulmonary disease 2018 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 171 participants
Very low

Escitalopram vs placebo

Dropouts due to adverse events · adults experiencing acute traumatic stress symptoms

1 finding from 1 review

Early pharmacological interventions for prevention of post‐traumatic stress disorder (PTSD) in individuals… 2024 · Cochrane Headline outcomes only
no estimate extracted
1 study · 31 participants
Very low

Hydrocortisone vs placebo

Dropouts due to adverse events · adults experiencing acute traumatic stress symptoms

Hydrocortisone showed no clear difference in dropouts due to adverse events at 3 months compared with placebo (low certainty).

1 finding from 1 review

Early pharmacological interventions for prevention of post‐traumatic stress disorder (PTSD) in individuals… 2024 · Cochrane Headline outcomes only
RR 3.19 [0.13, 75.43]
2 studies · 182 participants
Low

Gabapentin vs placebo

Dropouts due to adverse events · adults (aged 18 and older) exposed to a traumatic event

The review found no eligible studies for this question.

1 finding from 1 review

Early pharmacological interventions for universal prevention of post‐traumatic stress disorder (PTSD) 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Hydrocortisone vs placebo

Dropouts due to adverse events · adults (aged 18 and older) exposed to a traumatic event

The review found no eligible studies for this question.

1 finding from 1 review

Early pharmacological interventions for universal prevention of post‐traumatic stress disorder (PTSD) 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Propranolol vs placebo

Dropouts due to adverse events · adults (aged 18 and older) exposed to a traumatic event

The review found no eligible studies for this question.

1 finding from 1 review

Early pharmacological interventions for universal prevention of post‐traumatic stress disorder (PTSD) 2022 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Tricylic antidepressant vs placebo

Adverse events (disease‐related: all physical symptoms); · chronic obstructive pulmonary disease (COPD) with depression

1 finding from 1 review

Pharmacological interventions for the treatment of depression in chronic obstructive pulmonary disease 2018 · Cochrane Headline outcomes only
no estimate extracted
1 study · 30 participants
Very low