What do systematic reviews say?

Comparison 2: 2 days injectable benzylpenicillin + injectable gentamicin followed by 5 days oral amoxicillin vs 7 days injectable benzylpenicillin + injectable gentamicin

Comparison 2: 2 days injectable benzylpenicillin + injectable… showed no clear difference in adverse events compared with 7 days injectable benzylpenicillin + injectable gentamicin (moderate certainty).

• Community‐based antibiotic delivery for possible serious bacterial infections in neonates in low‐ and middle‐income… 2019 · Cochrane Headline outcomes only
  RR 1.39 [0.67, 2.87]
  3 studies · 2036 participants
  Moderate

Comparison 2: any simplified antibiotic regimen vs 7 days injectable benzylpenicillin + injectable gentamicin

Comparison 2: any simplified antibiotic regimen showed no clear difference in adverse events compared with the standard antibiotic regimen (7 days injectable benzylpenicillin… (moderate certainty).

• Community‐based antibiotic delivery for possible serious bacterial infections in neonates in low‐ and middle‐income… 2019 · Cochrane Headline outcomes only
  RR 1.38 [0.79, 2.41]
  3 studies · 3476 participants
  Moderate

Comparison 2: 7 days oral amoxicillin + injectable gentamicin vs 7 days injectable benzylpenicillin + injectable gentamicin

Comparison 2: 7 days oral amoxicillin + injectable gentamicin showed no clear difference in adverse events compared with 7 days injectable benzylpenicillin + injectable gentamicin (moderate certainty).

• Community‐based antibiotic delivery for possible serious bacterial infections in neonates in low‐ and middle‐income… 2019 · Cochrane Headline outcomes only
  RR 1.35 [0.72, 2.53]
  3 studies · 2001 participants
  Moderate

Comparison 2: 2 days oral amoxicillin + injectable gentamicin followed by 5 days oral amoxicillin vs 7 days injectable benzylpenicillin + injectable gentamicin

• Community‐based antibiotic delivery for possible serious bacterial infections in neonates in low‐ and middle‐income… 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 893 participants
  High

Comparison 2: 7 days oral amoxicillin vs 7 days injectable benzylpenicillin + injectable gentamicin

• Community‐based antibiotic delivery for possible serious bacterial infections in neonates in low‐ and middle‐income… 2019 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 1406 participants
  Moderate

Ceftazidime vs 7 days injectable benzylpenicillin + injectable gentamicin

• Antibiotic regimens for early‐onset neonatal sepsis 2021 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 55 participants
  Very low

Ampicillin plus gentamicin vs penicillin plus gentamicin

It is very uncertain whether ampicillin plus gentamicin changes serious adverse events maximum compared with penicillin plus gentamicin (very low certainty).

• Antibiotic regimens for early‐onset neonatal sepsis 2021 · Cochrane Headline outcomes only
  RR 0.93 [0.72, 1.21]
  1 study · 283 participants
  Very low