Findings

What do systematic reviews say?

4 questions · 4 findings · 4 reviews · Emergency and Critical Care

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No studies found 0 · 0%GRADE not reported 1 · 25%Very low 1 · 25%Low 1 · 25%Moderate 1 · 25%High 0 · 0%

Oxygenation vs no oxygenation during the apnoeic period preceding intubation

Adverse eventse · people requiring tracheal intubation

1 finding from 1 review

Oxygenation during the apnoeic phase preceding intubation in adults in prehospital, emergency department, intensive… 2023 · Cochrane Headline outcomes only
no estimate extracted
10 studies · 997 participants
GRADE not reported

Early intervention (mobilization or active exercise) vs usual care

Adverse events Proportion of participants with one or more events, or proportion of intervention sessions where an event occurred (falls, accidental dislodgement of attachments, haemodynamic instability, oxygen desaturation or any other adverse ev... · critically ill, mechanically ventilated adults

1 finding from 1 review

Early intervention (mobilization or active exercise) for critically ill adults in the intensive care unit 2018 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 690 participants
Low

Higher vs lower FiO2 or targets of arterial oxygenation

Proportion of participants with 1 or more serious adverse events according to International Conference on Harmonisation Good Clinical Practice (ICH‐GCP) · adults admitted to the ICU

It is very uncertain whether higher changes proportion of participants with ≥ 1 serious adverse events according… compared with lower FiO2 or targets of arterial oxygenation (very low certainty).

1 finding from 1 review

Higher versus lower fractions of inspired oxygen or targets of arterial oxygenation for adults admitted to the… 2023 · Cochrane Headline outcomes only
RR 1.01 [0.96, 1.06]
17 studies · 9466 participants
Very low

HFNC vs standard oxygen therapy

Adverse events Respiratory infection (pneumonia) Nasal mucosa or skin trauma · adults in the ICU, requiring respiratory support

HFNC showed no clear difference in adverse events Respiratory infection (pneumonia) Nasal mucosa or… compared with standard oxygen therapy (moderate certainty).

1 finding from 1 review

High‐flow nasal cannulae for respiratory support in adult intensive care patients 2021 · Cochrane Headline outcomes only
RR 0.72 [0.48, 1.09]
4 studies · 1057 participants
Moderate