Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

18 questions · 18 findings · 1 reviews · All outcomes

No studies found 6 · 33.3%GRADE not reported 8 · 44.4%Very low 4 · 22.2%Low 0 · 0%Moderate 0 · 0%High 0 · 0%

Metronidazole + SRP vs Amoxicillin + metronidazole + SRP

Adverse events · Adults with periodontitis (chronic and aggressive)

Metronidazole + SRP showed no clear difference in adverse events compared with amoxicillin + metronidazole + SRP; GRADE not reported.

1 finding from 1 review

Amoxicillin + metronidazole + SRP vs Clarithromycin + SRP

Adverse events · Adults with aggressive periodontitis

Amoxicillin + metronidazole + SRP showed no clear difference in adverse events compared with clarithromycin + SRP; GRADE not reported.

1 finding from 1 review

Clarithromycin + SRP vs SRP

Adverse events · Adults with periodontitis (chronic and aggressive)

Clarithromycin + SRP showed no clear difference in adverse events compared with SRP; GRADE not reported.

1 finding from 1 review

Metronidazole + SRP vs SRP

Adverse events · Adults with periodontitis (chronic and aggressive)

It is very uncertain whether metronidazole + SRP changes adverse events compared with SRP (very low certainty).

1 finding from 1 review

Azithromycin + SRP vs SRP

Adverse events · Adults with periodontitis (chronic and aggressive)

It is very uncertain whether azithromycin + SRP changes adverse events compared with SRP (very low certainty).

1 finding from 1 review

Amoxicillin + metronidazole + SRP vs SRP

Adverse events · Adults with periodontitis (chronic and aggressive)

It is very uncertain whether amoxicillin + metronidazole + SRP changes adverse events compared with SRP (very low certainty).

1 finding from 1 review

Doxycycline + SRP vs Amoxicillin + metronidazole + SRP

Adverse events · Adults with aggressive periodontitis

Doxycycline + SRP showed no clear difference in adverse events compared with amoxicillin + metronidazole + SRP; GRADE not reported.

1 finding from 1 review