Findings

What do systematic reviews say?

14 questions · 14 findings · 5 reviews · Pain, Palliative and Supportive Care

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 6 · 42.9%Low 2 · 14.3%Moderate 3 · 21.4%High 3 · 21.4%

Topical NSAIDs vs topical placebo

All topical NSAIDs Local adverse events · adults with strains, sprains, or muscle pull

1 finding from 1 review

Topical NSAIDs for acute musculoskeletal pain in adults 2015 · Cochrane Headline outcomes only
no estimate extracted
42 studies · 6125 participants
High

Topical NSAIDs vs topical placebo

All topical NSAIDs Systemic adverse events · adults with strains, sprains, or muscle pull

1 finding from 1 review

Topical NSAIDs for acute musculoskeletal pain in adults 2015 · Cochrane Headline outcomes only
no estimate extracted
38 studies · 5372 participants
High

Topical NSAIDs vs topical placebo

All topical NSAIDs Withdrawals ‐ adverse events · adults with strains, sprains, or muscle pull

1 finding from 1 review

Topical NSAIDs for acute musculoskeletal pain in adults 2015 · Cochrane Headline outcomes only
no estimate extracted
42 studies · 5790 participants
High

Topical NSAIDs vs topical placebo

Serious adverse events · adults with strains, sprains, or muscle pull

1 finding from 1 review

Topical NSAIDs for acute musculoskeletal pain in adults 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Low

Intervention not reported

Adverse events · people with cancer pain

1 finding from 1 review

Oral nonsteroidal anti‐inflammatory drugs (NSAIDs) for cancer pain in adults 2017 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Very low

Intervention not reported

Serious adverse events · people with cancer pain

1 finding from 1 review

Oral nonsteroidal anti‐inflammatory drugs (NSAIDs) for cancer pain in adults 2017 · Cochrane Headline outcomes only
no estimate extracted
11 studies · 949 participants
Very low

Intervention not reported

Serious adverse events · adults with chronic musculoskeletal pain (osteoarthritis)

1 finding from 1 review

Topical NSAIDs for chronic musculoskeletal pain in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
30 participants
Very low

Intervention not reported

Systemic adverse events · adults with chronic musculoskeletal pain (osteoarthritis)

1 finding from 1 review

Topical NSAIDs for chronic musculoskeletal pain in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Low

Morphine vs NSAIDs

Adverse eventsPercentage of participants with any adverse event · patients undergoing knee arthroscopy

Morphine showed no clear difference in adverse eventsPercentage of participants with any adverse event compared with NSAIDs (moderate certainty).

1 finding from 1 review

Single dose intra‐articular morphine for pain control after knee arthroscopy 2016 · Cochrane Headline outcomes only
RR 0.75 [0.19, 3.04]
3 studies · 120 participants
Moderate

Celecoxib vs naproxen

Withdrawals due to adverse events · children and adolescents with chronic non‐cancer pain

1 finding from 1 review

Non‐steroidal anti‐inflammatory drugs (NSAIDs) for chronic non‐cancer pain in children and adolescents 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 242 participants
Very low

Rofecoxib vs naproxen

Withdrawals due to adverse events · children and adolescents with chronic non‐cancer pain

1 finding from 1 review

Non‐steroidal anti‐inflammatory drugs (NSAIDs) for chronic non‐cancer pain in children and adolescents 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 310 participants
Very low

Meloxicam vs naproxen

Withdrawals due to adverse events · children and adolescents with chronic non‐cancer pain

1 finding from 1 review

Non‐steroidal anti‐inflammatory drugs (NSAIDs) for chronic non‐cancer pain in children and adolescents 2017 · Cochrane Headline outcomes only
no estimate extracted
1 study · 225 participants
Very low

Intervention not reported

Topical ketoprofen gel Local adverse events · adults with chronic musculoskeletal pain (osteoarthritis)

1 finding from 1 review

Topical NSAIDs for chronic musculoskeletal pain in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 2621 participants
Moderate

Intervention not reported

Topical diclofenac gel or solution Local adverse events · adults with chronic musculoskeletal pain (osteoarthritis)

1 finding from 1 review

Topical NSAIDs for chronic musculoskeletal pain in adults 2016 · Cochrane Headline outcomes only
no estimate extracted
15 studies · 3658 participants
Moderate