Findings

What do systematic reviews say?

30 questions · 30 findings · 9 reviews · Musculoskeletal

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No studies found 9 · 30%GRADE not reported 1 · 3.3%Very low 3 · 10%Low 10 · 33.3%Moderate 6 · 20%High 1 · 3.3%

NSAIDs vs glucocorticoids

Total adverse events · acute gout

NSAIDs probably leads to higher total adverse events compared with glucocorticoids (moderate certainty).

1 finding from 1 review

Non‐steroidal anti‐inflammatory drugs for acute gout 2021 · Cochrane Headline outcomes only
RR 1.62 [1.03, 2.55]
Studies not reported
Moderate

NSAIDs vs placebo

Total adverse events · acute gout

NSAIDs showed no clear difference in total adverse events compared with placebo (low certainty).

1 finding from 1 review

Non‐steroidal anti‐inflammatory drugs for acute gout 2021 · Cochrane Headline outcomes only
RR 0.2 [0.01, 3.85]
Studies not reported
Low

Oral NSAIDs vs placebo

Adverse events · Adults with lateral elbow pain

1 finding from 1 review

Non‐steroidal anti‐inflammatory drugs (NSAIDs) for treating lateral elbow pain in adults 2013 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 292 participants
GRADE not reported

Oral NSAIDs vs glucocorticoid injection

Adverse events · Adults with lateral elbow pain

The review found no eligible studies for this question.

1 finding from 1 review

Non‐steroidal anti‐inflammatory drugs (NSAIDs) for treating lateral elbow pain in adults 2013 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

NSAIDs vs glucocorticoids

Withdrawals due to adverse events · acute gout

NSAIDs showed no clear difference in withdrawals due to adverse events compared with glucocorticoids (moderate certainty).

1 finding from 1 review

Non‐steroidal anti‐inflammatory drugs for acute gout 2021 · Cochrane Headline outcomes only
RR 2.8 [0.55, 14.22]
Studies not reported
Moderate

NSAIDs vs placebo

Withdrawals due to adverse events · acute gout

1 finding from 1 review

Non‐steroidal anti‐inflammatory drugs for acute gout 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
Low

Topical NSAIDs vs placebo

Adverse events · Adults with lateral elbow pain

Topical NSAIDs showed no clear difference in adverse events compared with placebo (low certainty).

1 finding from 1 review

Non‐steroidal anti‐inflammatory drugs (NSAIDs) for treating lateral elbow pain in adults 2013 · Cochrane Headline outcomes only
RR 1.55 [0.2, 12.14]
3 studies · 153 participants
Low

Oral NSAIDs vs placebo

Withdrawals due to adverse events · Adults with lateral elbow pain

The review found no eligible studies for this question.

1 finding from 1 review

Non‐steroidal anti‐inflammatory drugs (NSAIDs) for treating lateral elbow pain in adults 2013 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Oral NSAIDs vs glucocorticoid injection

Withdrawals due to adverse events · Adults with lateral elbow pain

The review found no eligible studies for this question.

1 finding from 1 review

Non‐steroidal anti‐inflammatory drugs (NSAIDs) for treating lateral elbow pain in adults 2013 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

COX‐2 NSAIDs vs placebo

Number of serious adverse events · patients with axSpA (AS and nr‐axSpA)

COX‐2 NSAIDs showed no clear difference in number of serious adverse events compared with placebo (moderate certainty).

1 finding from 1 review

Non‐steroidal anti‐inflammatory drugs (NSAIDs) for axial spondyloarthritis (ankylosing spondylitis and… 2015 · Cochrane Headline outcomes only
RR 0.92 [0.14, 6.21]
669 participants
Moderate

COX‐2 NSAIDs vs placebo

Withdrawals due to adverse events · patients with axSpA (AS and nr‐axSpA)

COX‐2 NSAIDs showed no clear difference in withdrawals due to adverse events compared with placebo (low certainty).

1 finding from 1 review

Non‐steroidal anti‐inflammatory drugs (NSAIDs) for axial spondyloarthritis (ankylosing spondylitis and… 2015 · Cochrane Headline outcomes only
RR 2.14 [0.36, 12.56]
669 participants
Low

Topical NSAIDs vs placebo

Withdrawals due to adverse events · Adults with lateral elbow pain

1 finding from 1 review

Non‐steroidal anti‐inflammatory drugs (NSAIDs) for treating lateral elbow pain in adults 2013 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 185 participants
Low

Traditional NSAIDs vs placebo

Number of serious adverse events · patients with axSpA (AS and nr‐axSpA)

Traditional NSAIDs showed no clear difference in number of serious adverse events compared with placebo (moderate certainty).

1 finding from 1 review

Non‐steroidal anti‐inflammatory drugs (NSAIDs) for axial spondyloarthritis (ankylosing spondylitis and… 2015 · Cochrane Headline outcomes only
RR 1.69 [0.36, 7.97]
671 participants
Moderate

Traditional NSAIDs vs placebo

Withdrawals due to adverse events · patients with axSpA (AS and nr‐axSpA)

Traditional NSAIDs showed no clear difference in withdrawals due to adverse events Due to adverse events compared with placebo (high certainty).

1 finding from 1 review

Non‐steroidal anti‐inflammatory drugs (NSAIDs) for axial spondyloarthritis (ankylosing spondylitis and… 2015 · Cochrane Headline outcomes only
RR 0.75 [0.46, 1.21]
1165 participants
High

Non‐selective NSAIDs vs selective cyclo‐oxygenase‐2 inhibitors

Total adverse events · acute gout

Non‐selective NSAIDs probably leads to higher total adverse events compared with selective cyclo‐oxygenase‐2 inhibitors (moderate certainty).

1 finding from 1 review

Non‐steroidal anti‐inflammatory drugs for acute gout 2021 · Cochrane Headline outcomes only
RR 1.94 [1.36, 2.78]
Studies not reported
Moderate

Non‐selective NSAIDs vs selective cyclo‐oxygenase‐2 inhibitors

Withdrawals due to adverse events · acute gout

Non‐selective NSAIDs probably leads to higher withdrawals due to adverse events compared with selective cyclo‐oxygenase‐2 inhibitors (moderate certainty).

1 finding from 1 review

Non‐steroidal anti‐inflammatory drugs for acute gout 2021 · Cochrane Headline outcomes only
RR 2.34 [1.33, 4.14]
Studies not reported
Moderate

NSAID injection vs glucocorticoid injection

Adverse events · adults (> 18 years of age) with trigger finger

It is very uncertain whether NSAID injection changes adverse events compared with glucocorticoid injection (very low certainty).

1 finding from 1 review

Non‐steroidal anti‐inflammatory drugs (NSAIDs) for trigger finger 2021 · Cochrane Headline outcomes only
RR 2
2 studies · 231 participants
Very low

Low‐dose colchicine vs NSAIDs

Serious adverse events · acute gout

The review found no eligible studies for this question.

1 finding from 1 review

Colchicine for acute gout 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Acupuncture vs NSAIDs

Serious adverse events · patients with hip osteoarthritis

The review found no eligible studies for this question.

1 finding from 1 review

Acupuncture for hip osteoarthritis 2018 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Low‐dose colchicine vs NSAIDs

Withdrawals due to adverse events · acute gout

The review found no eligible studies for this question.

1 finding from 1 review

Colchicine for acute gout 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found