Findings

What do systematic reviews say?

5 questions · 5 findings · 4 reviews · Oral and maxillofacial surgery

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No studies found 1 · 20%GRADE not reported 0 · 0%Very low 2 · 40%Low 1 · 20%Moderate 1 · 20%High 0 · 0%

Low‐level laser therapy vs Placebo (sham) laser therapy

Adverse events · Patients of any age in any setting requiring intervention for iatrogenic injury to the inferior alveolar or lingual nerve

The review found no eligible studies for this question.

1 finding from 1 review

Interventions for iatrogenic inferior alveolar and lingual nerve injury 2014 · Cochrane All outcomes
SoF row 'Adverse events': This outcome was not reported in the included studies.
0 studies
No studies found

CBT vs inactive control (usual care care, attention control, waitlist)

Adverse events · People aged 12 years and over with painful TMD lasting 3 months or longer

1 finding from 1 review

Psychological therapies for temporomandibular disorders (TMDs) 2022 · Cochrane All outcomes
Only 1 study reported adverse events as an outcome (Litt 2010): it found worsening symptoms in 13 people treated with an oral splint (as part of standard treatment) and 4 people treated with CBT.
1 study · 101 participants
Very low

CBT vs alternative treatment

Adverse events · People aged 12 years and over with painful TMD lasting 3 months or longer

1 finding from 1 review

Psychological therapies for temporomandibular disorders (TMDs) 2022 · Cochrane All outcomes
SoF: 3 studies reported minor adverse events in the control group; 1 study reported minor adverse events in psychological therapy group; 1 study reported that there were no adverse events. Results: NCT00066937 minor…
5 studies
Very low

Antifibrinolytic therapy (tranexamic acid or epsilon aminocaproic acid) vs Placebo, no intervention or usual care (with or without placebo)

Side effects or other adverse events · People with haemophilia (A or B) undergoing minor oral surgery or dental extractions

Antifibrinolytic therapy (tranexamic acid or epsilon aminocaproic… showed no clear difference in side effects or other adverse events compared with placebo, no intervention or usual care (with or without placebo) (low certainty).

1 finding from 1 review

Antifibrinolytic therapy for preventing oral bleeding in patients with haemophilia or Von Willebrand disease… 2019 · Cochrane All outcomes
Up to 10 days postoperative
RD 0.034 [-0.32, 0.38]
2 studies · 59 participants
Low

Antifibrinolytic therapy - locally-applied tranexamic acid (TXA) mouthwash/solution (SoF eligibility: TXA or EACA; all included trials used topical TXA) vs Placebo mouthwash

Adverse effects requiring withdrawal/discontinuation of study medication · People on continuous VKA treatment undergoing minor oral surgery or dental extractions (eligibility included DOACs and all ages; all four…

Antifibrinolytic therapy - locally-applied tranexamic acid (TXA)… showed no clear difference in side effects or other adverse events requiring withdrawal compared with placebo (placebo solution/mouthwash) (moderate certainty).

1 finding from 1 review

Antifibrinolytic therapy for preventing oral bleeding in people on anticoagulants undergoing minor oral surgery or… 2018 · Cochrane All outcomes
7 days
RD 0.00 [-0.04, 0.04]
2 studies · 128 participants
Moderate