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What do systematic reviews say?

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Evidence found and GRADE certainty

6 questions · 6 findings · 5 reviews · Hypertension

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 1 · 16.7%Low 4 · 66.7%Moderate 1 · 16.7%High 0 · 0%

Lower blood pressure targets vs standard blood pressure targets

Total serious adverse events · cardiovascular disease with high blood pressure

Lower blood pressure targets showed no clear difference in total serious adverse events compared with standard blood pressure targets (low certainty).

1 finding from 1 review

Higher BP target (< 150‐160/95‐105 mmHg) vs lower BP target (< 140/90 mmHg)

Serious adverse events: cardiovascular events · older adults with primary hypertension

Higher BP target (< 150‐160/95‐105 mmHg) showed no clear difference in cardiovascular serious adverse events compared with lower BP target (< 140/90 mmHg) (low certainty).

1 finding from 1 review

All doses of cerivastatin vs placebo

Withdrawals due to adverse events · participants with normal or abnormal lipid profiles

It is very uncertain whether all doses of cerivastatin changes withdrawals due to adverse events compared with placebo (very low certainty).

1 finding from 1 review