Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

9 questions · 9 findings · 3 reviews · Skin

No studies found 0 · 0%GRADE not reported 2 · 22.2%Very low 4 · 44.4%Low 2 · 22.2%Moderate 1 · 11.1%High 0 · 0%

Oral propranolol vs topical timolol

Adverse events experienced at short or long term ‐ general adverse events 24 weeks' · infantile haemangiomas (strawberry birthmarks) of the skin

It is very uncertain whether oral propranolol changes adverse events experienced at short or long term ‐ general adverse… compared with topical timolol (very low certainty).

1 finding from 1 review

Oral propranolol vs placebo

Adverse events experienced at short or long term ‐ Serious adverse events 24 weeks' · infantile haemangiomas (strawberry birthmarks) of the skin

Oral propranolol showed no clear difference in adverse events experienced at short or long term ‐ Serious adverse… compared with placebo (low certainty).

1 finding from 1 review

Benzoyl peroxide vs placebo or no treatment

Total number of participants with any adverse events (long‐term data) Treatment duration: range 10 weeks to 12 weeks · participants with acne

It is very uncertain whether benzoyl peroxide changes total number of participants with any adverse events (long‐term… compared with placebo or no treatment (very low certainty).

1 finding from 1 review

Benzoyl peroxide vs adapalene

Adverse event data · participants with acne

It is very uncertain whether benzoyl peroxide changes total number of participants with any adverse events (long‐term… compared with adapalene (very low certainty).

1 finding from 1 review

Benzoyl peroxide vs clindamycin

Total number of participants with any adverse events (long‐term data) Treatment duration: range 10 weeks to 12 weeks · participants with acne

Benzoyl peroxide showed no clear difference in total number of participants with any adverse events (long‐term… compared with clindamycin (moderate certainty).

1 finding from 1 review