Findings

What do systematic reviews say?

12 questions · 12 findings · 6 reviews · Neuromuscular

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No studies found 1 · 8.3%GRADE not reported 1 · 8.3%Very low 6 · 50%Low 2 · 16.7%Moderate 1 · 8.3%High 1 · 8.3%

Dextromethorphan and quinidine sulfate combination (DMQ) vs placebo

Adverse events · sialorrhea (excessive saliva) in people with motor neuron disease/amyotrophic lateral sclerosis

1 finding from 1 review

Treatment for sialorrhea (excessive saliva) in people with motor neuron disease/amyotrophic lateral sclerosis 2022 · Cochrane Headline outcomes only
no estimate extracted
1 participants
Moderate

Scopolamine (hyoscine) patches vs placebo

Adverse events · people with motor neuron disease/amyotrophic lateral sclerosis with sialorrhea (excessive saliva) (all fed via gastrostomy and most…

1 finding from 1 review

Treatment for sialorrhea (excessive saliva) in people with motor neuron disease/amyotrophic lateral sclerosis 2022 · Cochrane Headline outcomes only
no estimate extracted
10 participants
Very low

BM‐MSC vs no treatment

Adverse events, total · people with probable or definite amyotrophic lateral sclerosis/motor neuron disease (treated with riluzole)

BM‐MSC showed no clear difference in adverse events, total compared with no treatment (low certainty).

1 finding from 1 review

Cell‐based therapies for amyotrophic lateral sclerosis/motor neuron disease 2019 · Cochrane Headline outcomes only
RR 0.86 [0.62, 1.19]
1 study · 64 participants
Low

BM‐MSC vs no treatment

Serious adverse events · people with probable or definite amyotrophic lateral sclerosis/motor neuron disease (treated with riluzole)

BM‐MSC showed no clear difference in serious adverse events compared with no treatment (low certainty).

1 finding from 1 review

Cell‐based therapies for amyotrophic lateral sclerosis/motor neuron disease 2019 · Cochrane Headline outcomes only
RR 0.47 [0.13, 1.72]
1 study · 64 participants
Low

Repetitive transcranial magnetic stimulation (rTMS) vs sham rTMS

Withdrawals due to adverse events · patients with the treatment of amyotrophic lateral sclerosis or motor neuron disease

1 finding from 1 review

Repetitive transcranial magnetic stimulation for the treatment of amyotrophic lateral sclerosis or motor neuron disease 2013 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 50 participants
GRADE not reported

Radiotherapy vs botulinum toxin

Adverse events, reported as "negative experiences" · sialorrhea (excessive saliva) in people with motor neuron disease/amyotrophic lateral sclerosis

It is very uncertain whether radiotherapy changes adverse events, reported as "negative experiences" compared with botulinum toxin (very low certainty).

1 finding from 1 review

Treatment for sialorrhea (excessive saliva) in people with motor neuron disease/amyotrophic lateral sclerosis 2022 · Cochrane Headline outcomes only
RR 7 [1.04, 46.95]
1 study · 20 participants
Very low