High‐dose vs low‐dose colchicine
Total adverse events · acute gout
High‐dose may leads to higher total adverse events compared with low‐dose colchicine (low certainty).
1 finding from 1 review
- RR 2.11 [1.51, 2.95]1 study · 126 participantsLow
Findings
What do systematic reviews say?
13 questions · 13 findings · 5 reviews · Musculoskeletal
No studies found 1 · 7.7%GRADE not reported 4 · 30.8%Very low 3 · 23.1%Low 3 · 23.1%Moderate 1 · 7.7%High 1 · 7.7%
Other types of high tibial osteotomy (aHTO) vs closing wedge high tibial osteotomy (CW‐HTO)
Serious adverse events · patients with osteoarthritis of the knee
Other types of high tibial osteotomy (aHTO) showed no clear difference in serious adverse events compared with closing wedge high tibial osteotomy (CW‐HTO) (low certainty).
1 finding from 1 review
- RR 2.49 [0.64, 9.75]4 studies · 265 participantsLow
High‐dose vs low‐dose colchicine
Serious adverse events · acute gout
1 finding from 1 review
- no estimate extracted1 study · 126 participantsGRADE not reported
High‐dose vs low‐dose colchicine
Withdrawals due to adverse events · acute gout
1 finding from 1 review
- no estimate extracted1 study · 126 participantsGRADE not reported
Closing wedge high tibial osteotomy (CW‐HTO) vs unicompartmental knee arthroplasty
Adverse events · patients with osteoarthritis of the knee
It is very uncertain whether closing wedge high tibial osteotomy (CW‐HTO) changes adverse events compared with unicompartmental knee arthroplasty (very low certainty).
1 finding from 1 review
- RR 0.25 [0.06, 1.08]1 study · 60 participantsVery low
High‐dose colchicine vs placebo
Total adverse events · acute gout
High‐dose colchicine may leads to higher total adverse events compared with placebo (low certainty).
1 finding from 1 review
- RR 3.21 [2.01, 5.11]2 studies · 124 participantsLow
High‐dose colchicine vs placebo
Serious adverse events · acute gout
1 finding from 1 review
- no estimate extracted1 study · 111 participantsGRADE not reported
High‐dose colchicine vs placebo
Withdrawals due to adverse events · acute gout
1 finding from 1 review
- no estimate extracted1 study · 111 participantsGRADE not reported
Intermittent/cyclic etidronate 400 mg/day vs placebo
Serious adverse events · postmenopausal women with a higher risk for fracturesa
1 finding from 1 review
- Etidronate for the primary and secondary prevention of osteoporotic fractures in postmenopausal women 2024 · Cochrane Headline outcomes onlyno estimate extractedStudies not reportedVery low
Risedronate 5 mg/day vs placebo
Serious adverse events · pPostmenopausal women at higher risk of fractures1
Risedronate 5 mg/day showed no clear difference in serious adverse events compared with placebo (moderate certainty).
1 finding from 1 review
- Risedronate for the primary and secondary prevention of osteoporotic fractures in postmenopausal women 2022 · Cochrane Headline outcomes onlyRR 1 [0.94, 1.07]Studies not reportedModerate
Intermittent/cyclic etidronate 400 mg/day vs placebo
Withdrawals due to adverse events · postmenopausal women with a higher risk for fracturesa
It is very uncertain whether intermittent/cyclic etidronate 400 mg/day changes withdrawals due to adverse events compared with placebo (very low certainty).
1 finding from 1 review
- Etidronate for the primary and secondary prevention of osteoporotic fractures in postmenopausal women 2024 · Cochrane Headline outcomes onlyRR 1.09 [0.54, 2.18]Studies not reportedVery low
Risedronate 5 mg/day vs placebo
Withdrawals due to adverse events · pPostmenopausal women at higher risk of fractures1
Risedronate 5 mg/day showed no clear difference in withdrawals due to adverse events compared with placebo (high certainty).
1 finding from 1 review
- Risedronate for the primary and secondary prevention of osteoporotic fractures in postmenopausal women 2022 · Cochrane Headline outcomes onlyRR 0.98 [0.9, 1.07]Studies not reportedHigh
Intervention not reported
Severe adverse events or withdrawals (due to adverse events) ‐ not reported · People with hip or knee osteoarthritis
The review found no eligible studies for this question.
1 finding from 1 review
- High‐intensity versus low‐intensity physical activity or exercise in people with hip or knee osteoarthritis 2015 · Cochrane Headline outcomes onlyno estimate extractedStudies not reportedNo studies found