What do systematic reviews say?

Combined steroid and antibiotic therapy vs antibiotics alone

Combined steroid and antibiotic therapy showed no clear difference in adverse events at 3 to 12 months' compared with antibiotics alone (low certainty).

• Adjunctive steroid therapy versus antibiotics alone for acute endophthalmitis after intraocular procedure 2022 · Cochrane Headline outcomes only
  RR 1.41 [0.53, 3.74]
  3 studies · 227 participants
  Low

Intervention not reported

The intervention probably leads to lower adverse events (moderate certainty).

• Doxycycline plus ivermectin versus ivermectin alone for treatment of patients with onchocerciasis 2016 · Cochrane Headline outcomes only
  no estimate extracted
  2010 participants
  Moderate

PACK‐CXL with standard therapy vs Standard therapy alone (radiotherapy or chemoradiotherapy)

• Corneal collagen cross‐linking for bacterial infectious keratitis 2020 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 32 participants
  Low