Findings

What do systematic reviews say?

6 questions · 6 findings · 3 reviews · Common Mental Disorders

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No studies found 1 · 16.7%GRADE not reported 0 · 0%Very low 4 · 66.7%Low 1 · 16.7%Moderate 0 · 0%High 0 · 0%

Abrupt discontinuation vs continuation of long‐term antidepressants

Adverse events · participants with depressive or anxiety disorders

It is very uncertain whether abrupt discontinuation changes adverse events compared with continuation of long‐term antidepressants (very low certainty).

1 finding from 1 review

Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
OR 1.11 [0.62, 1.99]
7 studies · 1012 participants
Very low

Discontinuation by "tapering" vs usual family planning care

Adverse events · participants with depressive or anxiety disorders

It is very uncertain whether discontinuation by "tapering" changes adverse events compared with continuation (or usual care) (very low certainty).

1 finding from 1 review

Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
OR 1.06 [0.82, 1.38]
7 studies · 1479 participants
Very low

Discontinuation with high‐intensity psychological interventions vs continuation

Adverse events · participants with long‐term antidepressants for depressive disorders

1 finding from 1 review

Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
no estimate extracted
3 studies · 690 participants
Very low

Discontinuation of long‐term antidepressant with minimal intervention vs usual care

Adverse events · participants with long‐term antidepressants for depressive or anxiety disorders

The review found no eligible studies for this question.

1 finding from 1 review

Approaches for discontinuation versus continuation of long‐term antidepressant use for depressive and anxiety… 2021 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

Bupropion XL vs placebo

Withdrawals due to adverse events · adults with a history of SAD who do not fulfil criteria for major depressive disorder

Bupropion XL showed no clear difference in discontinuation due to adverse events compared with placebo (low certainty).

1 finding from 1 review

Second‐generation antidepressants for preventing seasonal affective disorder in adults 2019 · Cochrane Headline outcomes only
RR 1.68 [0.74, 3.79]
3 studies · 1048 participants
Low

Intervention not reported

MST vs ECT ‐ adverse events that led to discontinuation of treatment (short term) · patients with schizophrenia

1 finding from 1 review

Magnetic seizure therapy for treatment‐resistant depression 2021 · Cochrane Headline outcomes only
0.19 [0.01, 3.52]
1 study · 25 participants
Very low