Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

5 questions · 5 findings · 2 reviews · Musculoskeletal

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 2 · 40%Low 1 · 20%Moderate 1 · 20%High 1 · 20%

Antidepressants vs placebo

Total adverse events between 0 and 16 weeks · predominantly knee osteoarthritis

Antidepressant leads to higher total adverse events between 0 and 16 weeks compared with placebo (high certainty).

1 finding from 1 review

Antidepressants vs placebo

Serious adverse events between 0 and 16 weeks · predominantly knee osteoarthritis

Antidepressant showed no clear difference in serious adverse events between 0 and 16 weeks compared with placebo (low certainty).

1 finding from 1 review

Antidepressants vs placebo

Proportion of participants who withdrew due to adverse events between 0 and 14 weeks · predominantly knee osteoarthritis

Antidepressant probably leads to higher proportion of participants who withdrew due to adverse events… compared with placebo (moderate certainty).

1 finding from 1 review