Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

12 questions · 12 findings · 5 reviews · Eyes and Vision

No studies found 3 · 25%GRADE not reported 0 · 0%Very low 1 · 8.3%Low 2 · 16.7%Moderate 5 · 41.7%High 1 · 8.3%

Conventional occlusion vs atropine penalization

Adverse events (reported occurrence of: mild reduction in the visual acuity of the sound eye not requiring treatment; light sensitivity; skin, lid, or conjunctival irritation) Assessed at different time points (17 weeks or 2 years). · Participants of any age with either unilateral strabismic, anisometropic, or mixed (strabismic‐refractive) amblyopia; deprivation…
1 finding from 1 review

Tocilizumab every 4 weeks vs placebo

Adverse events at ≥ 12 months · adults aged over 50 years with giant cell arteritis

Tocilizumab every 4 weeks showed no clear difference in adverse events at ≥ 12 months compared with placebo (moderate certainty).

1 finding from 1 review

Tocilizumab weekly vs placebo + 52‐week taper

Adverse events at ≥ 12 months · adults aged over 50 years with giant cell arteritis

Tocilizumab weekly showed no clear difference in adverse events at ≥ 12 months compared with placebo + 52‐week taper (moderate certainty).

1 finding from 1 review

Tocilizumab weekly vs placebo + 26‐week taper

Adverse events at ≥ 12 months · adults aged over 50 years with giant cell arteritis

Tocilizumab weekly showed no clear difference in adverse events at ≥ 12 months compared with placebo + 26‐week taper (moderate certainty).

1 finding from 1 review

Patching vs active observation

Minor adverse events Defined as any adverse event within 8 weeks of surgery that does not require further intervention · people with intermittent exotropia, aged less than 11 years

The review found no eligible studies for this question.

1 finding from 1 review

Bilateral lateral rectus recession vs lateral rectus recession and medial rectus resection

Minor adverse events Defined as any adverse event within 8 weeks of surgery that does not require further intervention · people with intermittent exotropia, aged 3 to < 11 years

Bilateral lateral rectus recession showed no clear difference in minor adverse events Defined as any adverse event within 8 weeks of… compared with unilateral lateral rectus recession with medial rectus resection (low certainty).

1 finding from 1 review