Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

28 questions · 30 findings · 14 reviews · Developmental, Psychosocial and Learning Problems

No studies found 10 · 33.3%GRADE not reported 2 · 6.7%Very low 14 · 46.7%Low 4 · 13.3%Moderate 0 · 0%High 0 · 0%

Psychosocial risk management ('Resettle' programme) vs usual care

Death during study period · adults with antisocial personality disorder

It is very uncertain whether psychosocial risk management ('Resettle' programme) changes adverse events: death during the study period Timing of assessment:… compared with treatment‐as‐usual (very low certainty).

1 finding from 1 review

Intervention not reported

Serious adverse events Measured by: proportion of serious adverse events (total) Average study duration (range): not stated · children and adolescents aged 18 years and under diagnosed with ADHD

It is very uncertain whether the intervention changes serious adverse events Measured by: proportion of serious adverse… (very low certainty).

1 finding from 1 review

Intervention not reported

Withdrawal of methylphenidate due to non‐serious adverse events Measured by: proportion of participants withdrawn from treatment Average study duration (range): 5.60 months (0.6 months to 41 months) · children and adolescents aged 18 years and under diagnosed with ADHD
1 finding from 1 review

Intervention not reported

Withdrawal of methylphenidate due to adverse events of unknown severity Measured by: proportion of participants withdrawn from treatment Average study duration (range): 4.6 months (21 days to 36 months) · children and adolescents aged 18 years and under diagnosed with ADHD
1 finding from 1 review

Intervention not reported

Withdrawal of methylphenidate due to serious adverse events (non‐comparative cohort studies) Measured by: proportion of participants withdrawn from treatment Average study duration (range): 7.9 months (1 month to 37 months) · children and adolescents aged 18 years and under diagnosed with ADHD
1 finding from 1 review

Environmental interventions vs no intervention

Adverse events · children (aged 0–6 years)

The review found no eligible studies for this question.

2 findings from 1 review

Parent‐mediated communication intervention vs no intervention

Adverse events · children up to 5 years of age with a communication difficulty associated with any non‐progressive motor disorder acquired before 2 years…

The review found no eligible studies for this question.

1 finding from 1 review

Mechanically assisted walking training with body weight support vs the same dose of overground walking training

Adverse events (not measured) · children with cerebral palsy classified within GMFCS Levels I to IV and between 4 and 18 years of age

The review found no eligible studies for this question.

1 finding from 1 review

Mechanically assisted walking training without body weight support vs the same dose of overground walking training

Adverse events (not measured) · children with cerebral palsy classified within GMFCS Levels I to III and between 3 and 12 years of age

The review found no eligible studies for this question.

1 finding from 1 review