Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

152 questions · 155 findings · 73 reviews

No studies found 47 · 30.3%GRADE not reported 15 · 9.7%Very low 52 · 33.5%Low 32 · 20.6%Moderate 8 · 5.2%High 1 · 0.6%

Cyclosporin vs mycophenolate mofetil with pulse dexamethasone

Adverse effects (weeks 0 to 26): serious infection requiring hospitalisation · idiopathic steroid‐resistant nephrotic syndrome in children

Cyclosporin showed no clear difference in adverse events (weeks 0 to 26): serious infection requiring… compared with mycophenolate mofetil with pulse dexamethasone (low certainty).

1 finding from 1 review

Impulsive lifestyle counselling + treatment‐as‐usual vs usual care

Adverse events:incarceration Assessed by: incarceration between a 3‐ and 9‐month · adults with antisocial personality disorder

It is very uncertain whether impulsive lifestyle counselling + treatment‐as‐usual changes adverse events:incarceration Assessed by: incarceration between a 3‐… compared with treatment‐as‐usual alone (very low certainty).

1 finding from 1 review

Impulsive lifestyle counselling + treatment‐as‐usual vs usual care

Adverse events: death Assessed by: number of participant deaths between a 3‐ and 9‐month · adults with antisocial personality disorder

It is very uncertain whether impulsive lifestyle counselling + treatment‐as‐usual changes adverse events: death Assessed by: number of participant deaths… compared with treatment‐as‐usual alone (very low certainty).

1 finding from 1 review

Doxycycline vs prednisolone

Number of participants with grade 3‐4 (severe or life‐threatening) treatment‐related adverse events at 1 year (raw data) · bullous pemphigoid

Doxycycline probably leads to lower number of participants with grade 3‐4 (severe or life‐threatening)… compared with prednisolone (moderate certainty).

1 finding from 1 review

Application of heat vs application of cold

Adverse events due to treatment Minor adverse events, reported in studies as: exacerbation in pain after treatment; burn as a result of hot‐water immersion, or transient erythema, or adverse effects due to application of ice · people stung accidentally by bluebottle jellyfish (Physalia) and box jellyfish that do not cause Irukandji syndrome (Hawaiian box…

It is very uncertain whether application of heat changes adverse events due to treatment Minor adverse events, reported in… compared with application of cold (very low certainty).

1 finding from 1 review

Shock wave lithotripsy vs ureteroscopy with holmium laser or pneumatic lithotripsy

Serious adverse events or complications of treatment

It is very uncertain whether shock wave lithotripsy changes serious adverse events or complications of treatment compared with ureteroscopy with holmium laser or pneumatic lithotripsy (very low certainty).

1 finding from 1 review

Percutaneous nephrolithotripsy vs tubeless percutaneous nephrolithotripsy

Serious adverse events or complications of treatments

It is very uncertain whether percutaneous nephrolithotripsy changes serious adverse events or complications of treatments compared with tubeless percutaneous nephrolithotripsy (very low certainty).

1 finding from 1 review