Findings

What do systematic reviews say?

127 questions · 131 findings · 83 reviews

Sort:Best matchNewest Highest certainty Download CSV

No studies found 27 · 20.6%GRADE not reported 15 · 11.5%Very low 46 · 35.1%Low 23 · 17.6%Moderate 16 · 12.2%High 4 · 3.1%

Early vs delayed school starts

Unintended or adverse effects · students aged 13‐19

1 finding from 1 review

Later school start times for supporting the education, health, and well‐being of high school students 2017 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 207576 participants
Very low

HFNC vs NIPPV or NIV

Adverse events ‐ pneumonia · adults in the ICU, requiring respiratory support

It is very uncertain whether HFNC changes adverse events Respiratory infection (pneumonia) compared with NIPPV or NIV (very low certainty).

1 finding from 1 review

High‐flow nasal cannulae for respiratory support in adult intensive care patients 2021 · Cochrane Headline outcomes only
RR 0.51 [0.17, 1.52]
3 studies · 1750 participants
Very low

Decompressive craniectomy vs medical treatment

Adverse events assessed in various ways, up to 24 months · patients > 12 months of age with a severe traumatic brain injury and in a coma (post‐resuscitation GOS score ≤ 8 points) with raised,…

1 finding from 1 review

Decompressive craniectomy for the treatment of high intracranial pressure in closed traumatic brain injury 2019 · Cochrane Headline outcomes only
no estimate extracted
2 studies · 544 participants
Low

Intervention not reported

Incidence of adverse events ‐ isoniazid prophylaxis only · children with HIV infection aged 12 years and under

The intervention showed no clear difference in incidence of adverse events ‐ isoniazid prophylaxis only (moderate certainty).

1 finding from 1 review

Antibiotics for preventing lower respiratory tract infections in high‐risk children aged 12 years and under 2015 · Cochrane Headline outcomes only
RR 1.09 [0.55, 2.19]
2 studies · 810 participants
Moderate

Intervention not reported

Incidence of adverse events ‐ co‐trimoxazole prophylaxis only · children with HIV infection aged 12 years and under

The intervention showed no clear difference in incidence of adverse events ‐ co‐trimoxazole prophylaxis only (moderate certainty).

1 finding from 1 review

Antibiotics for preventing lower respiratory tract infections in high‐risk children aged 12 years and under 2015 · Cochrane Headline outcomes only
RR 0.9 [0.47, 1.73]
1 study · 534 participants
Moderate

Intervention not reported

Severe adverse events or withdrawals (due to adverse events) ‐ not reported · People with hip or knee osteoarthritis

The review found no eligible studies for this question.

1 finding from 1 review

High‐intensity versus low‐intensity physical activity or exercise in people with hip or knee osteoarthritis 2015 · Cochrane Headline outcomes only
no estimate extracted
Studies not reported
No studies found

HFNC vs standard oxygen therapy

Adverse events Respiratory infection (pneumonia) Nasal mucosa or skin trauma · adults in the ICU, requiring respiratory support

HFNC showed no clear difference in adverse events Respiratory infection (pneumonia) Nasal mucosa or… compared with standard oxygen therapy (moderate certainty).

1 finding from 1 review

High‐flow nasal cannulae for respiratory support in adult intensive care patients 2021 · Cochrane Headline outcomes only
RR 0.72 [0.48, 1.09]
4 studies · 1057 participants
Moderate