Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

137 questions · 138 findings · 58 reviews

No studies found 23 · 16.7%GRADE not reported 4 · 2.9%Very low 35 · 25.4%Low 31 · 22.5%Moderate 34 · 24.6%High 11 · 8%

160/4.5 mcg BDF single inhaler therapy vs current best practice

Non‐fatal serious adverse events · adults with asthma not well controlled on ICS

160/4.5 mcg BDF single inhaler therapy showed no clear difference in serious adverse events (non‐fatal) compared with current best practice (low certainty).

1 finding from 1 review

SiT for maintenance/relief vs higher‐dose ICS/LABA + SABA

Patients with serious adverse events · Studies recruited adults and adolescents aged 12 and older with chronic asthma

SiT for maintenance/relief showed no clear difference in patients with serious adverse events compared with higher‐dose ICS/LABA + SABA (moderate certainty).

1 finding from 1 review

160/4.5 mcg BDF single inhaler therapy vs current best practice

Withdrawals due to adverse events · adults with asthma not well controlled on ICS

160/4.5 mcg BDF single inhaler therapy probably leads to higher discontinuation due to adverse events compared with current best practice (moderate certainty).

1 finding from 1 review

Pharmacological interventions vs placebo

Adverse events: death ‐ at end of treatment (secondary outcome) · people with depression after stroke

It is very uncertain whether pharmacological interventions changes adverse events: death (secondary outcome) compared with placebo (very low certainty).

1 finding from 1 review

Psychological therapy vs usual care or attention control

Adverse events: death ‐ at end of treatment (secondary outcome) · people with depression after stroke

It is very uncertain whether psychological therapy changes adverse events: death ‐ at end of treatment (secondary outcome) compared with usual care and/or attention control (very low certainty).

1 finding from 1 review

Abiraterone + ADT vs ADT only

Discontinued treatment due to adverse events measured at a median · men with metastatic, hormone‐sensitive prostate cancer

Abiraterone + ADT probably leads to higher discontinued treatment due to adverse events measured at a median compared with ADT alone (moderate certainty).

1 finding from 1 review

Enteral vs enteral and parenteral nutrition

Adverse events: sepsis (as reported by study authors at end of study · critically ill adults admitted to the ICU for trauma, emergency, or post‐surgical care; population excludes participants with acute…

The review found no eligible studies for this question.

1 finding from 1 review