Abiraterone + ADT vs ADT only: Discontinued treatment due to adverse events measured at a median
Abiraterone + ADT probably leads to higher discontinued treatment due to adverse events measured at a median compared with ADT alone (moderate certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Abiraterone + ADT vs ADT alone Discontinued treatment due to adverse events measured at a median · men with metastatic, hormone‐sensitive prostate cancer Abiraterone + ADT probably leads to higher discontinued treatment due to adverse events measured at a median compared with ADT alone (moderate certainty). Abiraterone acetate in combination with androgen deprivation therapy compared to androgen deprivation… (2020) · Cochrane Headline outcomes only | RR 1.5 [1.17, 1.92] | 1 study · 1199 participants | Moderate |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Abiraterone acetate in combination with androgen deprivation therapy compared to androgen deprivation therapy only for metastatic… 2020 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.