Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,199 questions · 1,226 findings · 451 reviews

No studies found 289 · 23.6%GRADE not reported 121 · 9.9%Very low 350 · 28.5%Low 279 · 22.8%Moderate 139 · 11.3%High 48 · 3.9%

Acupuncture vs sham

Adverse events at up to 2 months' · women with PMS

It is very uncertain whether acupuncture changes adverse events at up to 2 months' compared with sham (very low certainty).

1 finding from 1 review

Irrigation with antibacterial solution vs irrigation with non‐antibacterial solution

Adverse events: abscess formation · participants undergoing clean, clean‐contaminated, contaminated or dirty surgical procedures

It is very uncertain whether irrigation with antibacterial solution changes adverse events: abscess formation compared with irrigation with non‐antibacterial solution (very low certainty).

1 finding from 1 review

Rifapentine plus isoniazid weekly vs isoniazid

Treatment‐limiting adverse events · HIV‐negative people at risk of TB infection1

Rifapentine plus isoniazid weekly probably leads to higher treatment‐limiting adverse events compared with isoniazid daily (moderate certainty).

1 finding from 1 review

Vitamin D vs placebo

Proportion of participants with one or more serious adverse events due to any cause · children and adults with predominantly mild to moderate asthma

Summary of findings table ‐ Vitamin D showed no clear difference in proportion of participants with one or more serious adverse events… compared with placebo (high certainty).

1 finding from 1 review