Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

260 questions · 267 findings · 107 reviews

No studies found 81 · 30.3%GRADE not reported 43 · 16.1%Very low 66 · 24.7%Low 40 · 15%Moderate 35 · 13.1%High 2 · 0.7%

CBT vs inactive control (usual care care, attention control, waitlist)

Adverse events · People aged 12 years and over with painful TMD lasting 3 months or longer
1 finding from 1 review
  • Only 1 study reported adverse events as an outcome (Litt 2010): it found worsening symptoms in 13 people treated with an oral splint (as part of standard treatment) and 4 people treated with CBT.
    1 study · 101 participants
    Very low

Hypnosis vs relaxation

Adverse events · People aged 12 years and over with painful TMD lasting 3 months or longer
1 finding from 1 review

Homeopathic medicinal products (non‐individualised treatment) vs placebo or usual care

Adverse events · children aged up to 16 years with ARTIs

It is very uncertain whether homeopathic medicinal products (non‐individualised treatment) changes adverse events compared with placebo or usual care (very low certainty).

1 finding from 1 review

Homeopathic medicinal products (individualised treatment) vs placebo or usual care

Adverse events · children aged up to 16 years with ARTIs

Homeopathic medicinal products (individualised treatment) showed no clear difference in adverse events compared with placebo or usual care (moderate certainty).

1 finding from 1 review

Glass ionomer-based sealant vs Resin-based sealant

Adverse events · 'Healthy' children with caries-free second primary molars, aged 3-5 years (schools and kindergartens, India and China)
1 finding from 1 review
  • 1 study reported adverse events as some discomfort such as nausea; 1 child experienced a strong gag reflex following the glass ionomer-based sealant while 8 children reported feeling uncomfortable after the fluoride…
    1 study · 100 participants
    Very low

Environmental interventions vs no intervention

Adverse events · children (aged 0–6 years)

The review found no eligible studies for this question.

2 findings from 1 review