Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

150 questions · 150 findings · 48 reviews

No studies found 19 · 12.7%GRADE not reported 21 · 14%Very low 40 · 26.7%Low 39 · 26%Moderate 23 · 15.3%High 8 · 5.3%

High‐dose corticosteroids vs moderate‐dose or no corticosteroids

Serious adverse events · adults with metastatic extradural spinal cord compression (without peptic ulceration or infection; mixed prognosis)

High‐dose corticosteroids probably leads to higher serious adverse events compared with moderate‐dose or no corticosteroids (moderate certainty).

1 finding from 1 review