Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

185 questions · 187 findings · 30 reviews

No studies found 32 · 17.1%GRADE not reported 4 · 2.1%Very low 58 · 31%Low 59 · 31.6%Moderate 29 · 15.5%High 5 · 2.7%

Azathioprine or 6‐mercaptopurine vs 5‐aminosalicylic acid (5‐ASA) (mesalazine)

Serious adverse events · people with surgically‐induced remission in Crohn's disease

It is very uncertain whether azathioprine or 6‐mercaptopurine changes serious adverse events compared with 5‐aminosalicylic acid (very low certainty).

1 finding from 1 review

Azathioprine or 6‐mercaptopurine vs anti TNF‐ɑ

Serious adverse events · people with surgically‐induced remission in Crohn's disease

It is very uncertain whether azathioprine or 6‐mercaptopurine changes serious adverse events compared with anti TNF‐α (very low certainty).

1 finding from 1 review

Intervention not reported

Serious adverse events · Patients with active Crohn's disease

The intervention showed no clear difference in serious adverse events (low certainty).

1 finding from 1 review

Usual care vs immunosuppressive withdrawal after combination therapy

Serious adverse events · Participants with Crohn's disease in remission

It is very uncertain whether usual care changes serious adverse events compared with immunosuppressive withdrawal after combination therapy (very low certainty).

1 finding from 1 review