Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

46 questions · 46 findings · 19 reviews

No studies found 5 · 10.9%GRADE not reported 0 · 0%Very low 18 · 39.1%Low 16 · 34.8%Moderate 6 · 13%High 1 · 2.2%

Antidepressants vs placebo

Total adverse events between 0 and 16 weeks · predominantly knee osteoarthritis

Antidepressant leads to higher total adverse events between 0 and 16 weeks compared with placebo (high certainty).

1 finding from 1 review

Antidepressants vs placebo

Serious adverse events between 0 and 16 weeks · predominantly knee osteoarthritis

Antidepressant showed no clear difference in serious adverse events between 0 and 16 weeks compared with placebo (low certainty).

1 finding from 1 review

Antidepressants vs placebo

Proportion of participants who withdrew due to adverse events between 0 and 14 weeks · predominantly knee osteoarthritis

Antidepressant probably leads to higher proportion of participants who withdrew due to adverse events… compared with placebo (moderate certainty).

1 finding from 1 review