Antidepressants vs placebo
Antidepressant leads to higher total adverse events between 0 and 16 weeks compared with placebo (high certainty).
- RR 1.27 [1.15, 1.41]9 studies · 2101 participantsHigh
Antidepressant leads to higher total adverse events between 0 and 16 weeks compared with placebo (high certainty).
Antidepressant showed no clear difference in serious adverse events between 0 and 16 weeks compared with placebo (low certainty).
It is very uncertain whether tricyclic antidepressant changes total number of adverse events patient interview compared with control (very low certainty).
Fluoxetine showed no clear difference in adverse events (at least 1 treatment‐emergent adverse event) compared with light therapy (low certainty).
It is very uncertain whether tricyclic antidepressant changes number of Withdrawals due to Adverse Events patient interview compared with control (very low certainty).
Antidepressant probably leads to higher proportion of participants who withdrew due to adverse events… compared with placebo (moderate certainty).