Findings

What do systematic reviews say?

28 questions · 28 findings · 6 reviews

Sort:Best matchNewest Highest certainty Download CSV

No studies found 9 · 32.1%GRADE not reported 8 · 28.6%Very low 9 · 32.1%Low 1 · 3.6%Moderate 1 · 3.6%High 0 · 0%

Amoxicillin + metronidazole + SRP vs SRP

Adverse events · Adults with periodontitis (chronic and aggressive)

It is very uncertain whether amoxicillin + metronidazole + SRP changes adverse events compared with SRP (very low certainty).

1 finding from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Long-term (≥ 1 year)
Most common adverse events were mild gastrointestinal disturbances, nausea and vomiting, metallic taste, and diarrhoea in the intervention group. Control group reported adverse events like hypothermia, mild…
2 studies · 389 participants
Very low

Clindamycin + SRP vs Doxycycline + SRP

Adverse events · Adults with aggressive periodontitis

The review found no eligible studies for this question.

1 finding from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
Long-term (≥ 1 year)
Included study has not reported adverse events
Studies not reported
No studies found

Doxycycline + SRP vs Amoxicillin + metronidazole + SRP

Adverse events · Adults with aggressive periodontitis

Doxycycline + SRP showed no clear difference in adverse events compared with amoxicillin + metronidazole + SRP; GRADE not reported.

1 finding from 1 review

Adjunctive systemic antimicrobials for the non‐surgical treatment of periodontitis 2020 · Cochrane All outcomes
One trial (Akincibay 2008) did not report this outcome; Xajigeorgiou 2006 reported mild gastrointestinal discomfort in 2 subjects from the AMOX + MTZ + SRP group.
1 study
GRADE not reported

Early vs delayed mobilisation

Adverse events: Shoulder complications · adults with minimally displaced or displaced (2‐part or 3‐part) proximal humeral fractures treated non‐surgically (5 trials)

1 finding from 1 review

Interventions for treating proximal humeral fractures in adults 2022 · Cochrane Headline outcomes only
no estimate extracted
4 studies · 259 participants
Very low

Surgical vs non‐surgical treatment

Adverse events / complications ‐ Number of participants with complications · (mainly older) adults with most types of displaced proximal humeral fracturesa (10 trials)

Surgical showed no clear difference in adverse events / complications ‐ Number of participants with… compared with non‐surgical treatment (low certainty).

1 finding from 1 review

Interventions for treating proximal humeral fractures in adults 2022 · Cochrane Headline outcomes only
RR 1.46 [0.92, 2.31]
3 studies · 391 participants
Low

Intervention not reported

Adverse events, complications and morbidity associated with (adeno)tonsillectomy and comparators [6 months] · children with obstructive sleep‐disordered breathing

1 finding from 1 review

Tonsillectomy or adenotonsillectomy versus non‐surgical management for obstructive sleep‐disordered breathing in… 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 20 participants
Very low

Intervention not reported

Adverse events, complications and morbidity associated with (adeno)tonsillectomy and comparators Expressed as the proportion of children experiencing adverse events [12 months] · children with obstructive sleep‐disordered breathing

1 finding from 1 review

Tonsillectomy or adenotonsillectomy versus non‐surgical management for obstructive sleep‐disordered breathing in… 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 73 participants
Very low

Intervention not reported

Adverse events, complications and morbidity associated with (adeno)tonsillectomy and comparators Expressed as the proportion of children experiencing a serious adverse event [7 months] · children with obstructive sleep‐disordered breathing

1 finding from 1 review

Tonsillectomy or adenotonsillectomy versus non‐surgical management for obstructive sleep‐disordered breathing in… 2015 · Cochrane Headline outcomes only
no estimate extracted
1 study · 397 participants
Moderate