Botulinum neurotoxin B leads to higher adverse events: dysphagia compared with placebo (high certainty).
It is very uncertain whether botulinum neurotoxin B changes proportion of participants with adverse events compared with placebo (very low certainty).
Botulinum neurotoxin B showed no clear difference in proportion of withdrawals due to adverse events compared with placebo (low certainty).
Summary of Findings Table ‐ OnabotulinumtoxinA 20U probably leads to higher major adverse events compared with placebo (moderate certainty).
Summary of Findings Table ‐ OnabotulinumtoxinA 20U showed no clear difference in total adverse events compared with placebo (low certainty).
Summary of Findings Table ‐ AbobotulinumtoxinA 50U may leads to higher total adverse events compared with placebo (low certainty).
Summary of Findings Table ‐ IncobotulinumtoxinA 20U showed no clear difference in total adverse events compared with placebo (low certainty).
Summary of Findings Table ‐ DaxibotulinumtoxinA 40U probably leads to higher total adverse events compared with placebo (moderate certainty).
Summary of Findings Table ‐ AbobotulinumtoxinA 50U showed no clear difference in major adverse events (eyelid ptosis, eyelid sensory disorder,… compared with placebo (moderate certainty).
The review found no eligible studies for this question.
BoNT‐A showed no clear difference in adverse events compared with placebo or sham (moderate certainty).
BoNT‐A showed no clear difference in adverse events compared with serial casting (low certainty).
It is very uncertain whether radiotherapy changes adverse events, reported as "negative experiences" compared with botulinum toxin (very low certainty).
The review found no eligible studies for this question.
The intervention showed no clear difference in number of Adverse Events (AEs) ( (low certainty).
The review found no eligible studies for this question.
It is very uncertain whether systemic antispasticity drugs changes adverse events Adverse events per participant compared with placebo (very low certainty).
The review found no eligible studies for this question.