Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

1,228 questions · 1,245 findings · 383 reviews

No studies found 403 · 32.4%GRADE not reported 128 · 10.3%Very low 385 · 30.9%Low 232 · 18.6%Moderate 81 · 6.5%High 16 · 1.3%

Movement therapies vs usual care

Adverse events post‐intervention Number of people reporting an adverse event before completing the intervention · patients with fibromyalgia

It is very uncertain whether movement therapies changes adverse events post‐intervention Number of people reporting an… compared with usual care (very low certainty).

1 finding from 1 review

Psychological therapies vs usual care

Adverse events post‐intervention Number of people reporting an adverse event before completing the intervention · patients with fibromyalgia

Psychological therapies showed no clear difference in adverse events post‐intervention Number of people reporting an… compared with usual care (low certainty).

1 finding from 1 review

Blue‐light filtering intraocular lenses (IOL) vs non blue‐light filtering IOL

Proportion of participants with adverse events with a probable causal link with the study interventions at six months · adults undergoing cataract surgery with IOL implantation

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Adverse outcome: unintended adverse events attributable to the intervention ATCS+, IVR, unidirectional versus various controls · participants at risk of under‐immunisation (children, adolescents and adults)

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Adverse events 1. All adverse events 2. Drop‐outs due to adverse events Intervention vs alpha‐glucosidase inhibitors [30 weeks] · participants with type 2 diabetes mellitus

The intervention may leads to lower adverse events 1. All adverse events 2. Drop‐outs due to adverse… (low certainty).

1 finding from 1 review

Intervention not reported

Adverse outcome: unintended adverse events attributable to the intervention Multimodal/complex intervention, ATCS Plus, IVR versus various controls · participants at risk of developing long‐term conditions

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Adverse events 1. All adverse events 2. Drop‐outs due to adverse events Interventions vs thiazolidinediones [1. 6 months to 12 months] [2. 24 weeks to 52 weeks] · participants with type 2 diabetes mellitus

The intervention may leads to lower adverse events 1. All adverse events 2. Drop‐outs due to adverse… (low certainty).

1 finding from 1 review

Intervention not reported

Adverse outcome: unintended adverse events attributable to the intervention Multimodal/complex intervention, ATCS Plus, IVR, unidirectional versus various controls · participants at risk for breast, colorectal or cervical cancer; or osteoporosis

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Adverse outcome: unintended adverse events attributable to the intervention Multimodal/complex intervention, ATCS Plus, IVR, unidirectional versus various controls · patients with various conditions or at risk of low adherence to medication or laboratory tests

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Adverse outcome: unintended adverse events attributable to the intervention Multimodal/complex intervention, ATCS Plus, IVR, unidirectional ATCS versus various controls · patients with hypertension

The review found no eligible studies for this question.

1 finding from 1 review

Intervention not reported

Adverse events 1. All adverse events 2. Drop‐outs due to adverse events 3. Severe hypoglycaemia a. Intervention vs placebo [1a. 24 weeks] [2a. 24 weeks to 56 weeks] b. Intervention vs metformin [1b. 6 months to 4 years] [2b. 24 weeks to 4 years] [... · participants with type 2 diabetes mellitus

The intervention showed no clear difference in adverse events 1. All adverse events 2. Drop‐outs due to adverse… (low certainty).

1 finding from 1 review