Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

419 questions · 420 findings · 128 reviews

No studies found 71 · 16.9%GRADE not reported 69 · 16.4%Very low 96 · 22.9%Low 116 · 27.6%Moderate 63 · 15%High 5 · 1.2%

Keratinocyte growth factor (KGF; palifermin or repifermin), intravenous vs placebo

Adverse events · Adults with cancer receiving treatment
1 finding from 1 review

Azoles vs placebo

Adverse events · participants with confirmed toenail onychomycosis

Azole showed no clear difference in adverse events compared with placebo (moderate certainty).

1 finding from 1 review

Antifibrinolytic therapy - locally-applied tranexamic acid (TXA) mouthwash/solution (SoF eligibility: TXA or EACA; all included trials used topical TXA) vs Placebo mouthwash

Adverse effects requiring withdrawal/discontinuation of study medication · People on continuous VKA treatment undergoing minor oral surgery or dental extractions (eligibility included DOACs and all ages; all four…

Antifibrinolytic therapy - locally-applied tranexamic acid (TXA)… showed no clear difference in side effects or other adverse events requiring withdrawal compared with placebo (placebo solution/mouthwash) (moderate certainty).

1 finding from 1 review

Intervention not reported

Adverse events: · adults and children with cystic fibrosis
1 finding from 1 review