Metformin showed no clear difference in adverse events ‐ Severe compared with metformin combined with oral contraceptive pill (OCP) (low certainty).
Metformin may leads to higher adverse events ‐ Severe compared with oral contraceptive pill (OCP) (low certainty).
Oral methotrexate showed no clear difference in adverse events: severe compared with oral chloroquine (low certainty).
Oral methotrexate showed no clear difference in adverse events: severe compared with placebo (moderate certainty).
The intervention showed no clear difference in adverse events 1. All adverse events 2. Drop‐outs due to adverse… (low certainty).
Oral contraceptive pill (OCP) may leads to lower adverse events ‐ Severe compared with metformin combined with OCP (low certainty).
It is very uncertain whether oral contraceptive pill (OCP) changes adverse events ‐ Severe compared with metformin combined with OCP (very low certainty).
It is very uncertain whether surgery plus whole brain radiotherapy (WBRT) changes adverse events (severe) compared with stereotactic radiosurgery (very low certainty).
Azathioprine may leads to lower severe adverse events compared with methotrexate (low certainty).
Abiraterone + ADT leads to higher grades III to V adverse events (severe and life threatening, as per… compared with ADT alone (high certainty).