Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

31 questions · 31 findings · 12 reviews

No studies found 5 · 16.1%GRADE not reported 2 · 6.5%Very low 13 · 41.9%Low 8 · 25.8%Moderate 3 · 9.7%High 0 · 0%

Primary‐level worker‐led collaborative care vs usual care

Adverse events ‐ death · adults with common mental disorders

It is very uncertain whether primary‐level worker‐led collaborative care changes adverse events ‐ death compared with usual care (very low certainty).

1 finding from 1 review

Non‐integrated models of care ‐ Assertive community treatment only/Intensive case management/Specialised case management services vs usual care

Adverse event: Death ‐ not measured · people with both severe mental illness and substance misuse

The review found no eligible studies for this question.

1 finding from 1 review

Azathioprine vs methotrexate

Adverse event causing death or study drug discontinuation · adults with renal vasculitis for maintenance therapy

Azathioprine showed no clear difference in adverse events causing death or study drug discontinuation compared with methotrexate (low certainty).

1 finding from 1 review

Psychological therapy vs usual care or attention control

Adverse events: death ‐ at end of treatment (Analysis 1.14) · people with stroke

It is very uncertain whether psychological therapy changes adverse events: death ‐ at end of treatment (Analysis 2.16) compared with usual care and/or attention control (very low certainty).

1 finding from 1 review

Psychological therapy vs usual care or attention control

Adverse events: death ‐ at end of treatment (secondary outcome) · people with depression after stroke

It is very uncertain whether psychological therapy changes adverse events: death ‐ at end of treatment (secondary outcome) compared with usual care and/or attention control (very low certainty).

1 finding from 1 review

Impulsive lifestyle counselling + treatment‐as‐usual vs usual care

Adverse events: death Assessed by: number of participant deaths between a 3‐ and 9‐month · adults with antisocial personality disorder

It is very uncertain whether impulsive lifestyle counselling + treatment‐as‐usual changes adverse events: death Assessed by: number of participant deaths… compared with treatment‐as‐usual alone (very low certainty).

1 finding from 1 review

Psychosocial risk management ('Resettle' programme) vs usual care

Death during study period · adults with antisocial personality disorder

It is very uncertain whether psychosocial risk management ('Resettle' programme) changes adverse events: death during the study period Timing of assessment:… compared with treatment‐as‐usual (very low certainty).

1 finding from 1 review