What do systematic reviews say?

1450 ppm F toothpaste vs 440 ppm F toothpaste

The review found no eligible studies for this question.

• Fluoride toothpastes of different concentrations for preventing dental caries 2019 · Cochrane All outcomes
  Adverse effects of toothpaste: no studies reported this outcome.
  0 studies
  No studies found

1450 ppm F toothpaste vs 250 ppm F toothpaste

The review found no eligible studies for this question.

• Fluoride toothpastes of different concentrations for preventing dental caries 2019 · Cochrane All outcomes
  Adverse effects of toothpaste: no studies reported this outcome.
  0 studies
  No studies found

1055 to 1100 ppm F toothpaste vs 500 to 550 ppm F toothpaste

• Fluoride toothpastes of different concentrations for preventing dental caries 2019 · Cochrane All outcomes

  12 months
  Adverse effects of toothpaste: not estimable. "There were no reports on adverse effects, but some children complained about the taste of the dentifrice" (Cardoso 2014); 195 participants (1 RCT); low-certainty.
  1 study · 195 participants
  Low

Fluoride toothpaste vs Placebo (non-fluoride) toothpaste or fluoride toothpaste of a different concentration

• Fluoride toothpastes of different concentrations for preventing dental caries 2019 · Cochrane All outcomes

  Closest to 36 months
  16 studies assessed possible side effects, principally oral (soft tissue) pathologies and tooth staining. 6 studies reported no untoward events; 6 reported greater staining in the stannous fluoride group; 1 reported no…
  16 studies
  GRADE not reported

1500 ppm F toothpaste vs Non-fluoride (0 ppm F) placebo toothpaste

• Fluoride toothpastes of different concentrations for preventing dental caries 2019 · Cochrane All outcomes

  24 months
  Adverse effects of toothpaste: not estimable; 0 events reported (Fan 2008); 998 participants (1 RCT); low-certainty.
  1 study · 998 participants
  Low