Findings

What do systematic reviews say?

6 questions · 6 findings · 5 reviews · Hypertension

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 3 · 50%Low 2 · 33.3%Moderate 1 · 16.7%High 0 · 0%

Combination therapy vs monotherapy

Withdrawals due to adverse events · people with primary hypertension

It is very uncertain whether combination therapy changes withdrawals due to adverse effects compared with monotherapy (very low certainty).

1 finding from 1 review

First‐line combination therapy versus first‐line monotherapy for primary hypertension 2020 · Cochrane Headline outcomes only
RR 0.85 [0.53, 1.35]
3 studies · 568 participants
Very low

Combination with potassium‐sparing diuretics vs monotherapy

Withdrawals due to adverse events · people with primary hypertension

1 finding from 1 review

First‐line combination therapy versus first‐line monotherapy for primary hypertension 2020 · Cochrane Headline outcomes only
no estimate extracted
1 study · 200 participants
Very low

Intervention not reported

Withdrawal due to adverse effects · adults with primary hypertension

1 finding from 1 review

Blood pressure‐lowering efficacy of monotherapy with thiazide diuretics for primary hypertension 2014 · Cochrane Headline outcomes only
no estimate extracted
20 studies · 3698 participants
Very low

Intervention not reported

Withdrawals due to adverse effects 5 years · Adults with mild hypertension and no cardiovascular disease

The intervention probably leads to higher withdrawals due to adverse effects 5 years (moderate certainty).

1 finding from 1 review

Pharmacotherapy for mild hypertension 2012 · Cochrane Headline outcomes only
RR 4.8 [4.14, 5.57]
1 study · 17354 participants
Moderate

Uric acid lowering therapies (UAR) vs placebo

Withdrawals due to adverse events · hyperuricaemia in people with hypertension

Uric acid‐lowering drug showed no clear difference in adverse events (withdrawals due to side effects) compared with placebo (low certainty).

1 finding from 1 review

Pharmacotherapy for hyperuricaemia in hypertensive patients 2020 · Cochrane Headline outcomes only
RR 1.86 [0.43, 8.1]
3 studies · 241 participants
Low

Any antihypertensive drug vs placebo or no treatment

Withdrawals due to adverse events · adults 60 years or older with primary hypertension

Antihypertensive drug may leads to higher withdrawals due to adverse effects Mean duration of 4.6 years compared with placebo or no treatment (low certainty).

1 finding from 1 review

Pharmacotherapy for hypertension in adults 60 years or older 2019 · Cochrane Headline outcomes only
RR 2.91 [2.56, 3.3]
4 studies · 11310 participants
Low