Findings

What do systematic reviews say?

6 questions · 6 findings · 2 reviews · Neonatal

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No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 5 · 83.3%Moderate 0 · 0%High 1 · 16.7%

Vitamin D given to infants vs placebo or no treatment

Hypercalcaemia · term breastfed infants to prevent vitamin D deficiency and improve bone health

Vitamin D given to infants showed no clear difference in adverse effects (hypercalcaemia) compared with placebo or no treatment (low certainty).

1 finding from 1 review

Vitamin D supplementation for term breastfed infants to prevent vitamin D deficiency and improve bone health 2020 · Cochrane Headline outcomes only
RR 1.45 [0.54, 3.86]
1 study · 98 participants
Low

Vitamin D given to lactating mothers vs placebo or no treatment

Hypercalcaemia · term breastfed infants to prevent vitamin D deficiency and improve bone health

Vitamin D given to lactating mothers showed no clear difference in adverse effects (hypercalcaemia) compared with placebo or no treatment (low certainty).

1 finding from 1 review

Vitamin D supplementation for term breastfed infants to prevent vitamin D deficiency and improve bone health 2020 · Cochrane Headline outcomes only
RR 1.31 [0.51, 3.32]
3 studies · 557 participants
Low

Intervention not reported

Adverse effects: fever 48 to 72 hours · infants 1 to 6 months of age

The intervention showed no clear difference in adverse effects: fever 48 to 72 hours (low certainty).

1 finding from 1 review

Vitamin A supplementation for the prevention of morbidity and mortality in infants one to six months of age 2016 · Cochrane Headline outcomes only
RR 0.94 [0.83, 1.07]
3 studies · 3187 participants
Low

Intervention not reported

Adverse effects: vomiting 48 to 72 hours · infants 1 to 6 months of age

The intervention showed no clear difference in adverse effects: vomiting 48 to 72 hours (low certainty).

1 finding from 1 review

Vitamin A supplementation for the prevention of morbidity and mortality in infants one to six months of age 2016 · Cochrane Headline outcomes only
RR 0.95 [0.67, 1.35]
2 studies · 2187 participants
Low

Intervention not reported

Adverse effects: diarrhoea 48 to 72 hours · infants 1 to 6 months of age

The intervention showed no clear difference in adverse effects: diarrhoea 48 to 72 hours (low certainty).

1 finding from 1 review

Vitamin A supplementation for the prevention of morbidity and mortality in infants one to six months of age 2016 · Cochrane Headline outcomes only
RR 1.07 [0.82, 1.4]
3 studies · 2176 participants
Low

Intervention not reported

Adverse effects: bulging fontanelle within 48 to 72 hours · infants 1 to 6 months of age

The intervention leads to higher adverse effects: bulging fontanelle within 48 to 72 hours (high certainty).

1 finding from 1 review

Vitamin A supplementation for the prevention of morbidity and mortality in infants one to six months of age 2016 · Cochrane Headline outcomes only
RR 3.1 [1.89, 5.09]
9 studies · 13493 participants
High