What do systematic reviews say?

Group B cognitive behavioural therapy: cognitive behavioural therapy + supportive therapy vs supportive therapy

• Interventions for prodromal stage of psychosis 2019 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Chemotherapy vs best supportive care

Chemotherapy probably leads to higher severe adverse effects compared with best supportive care (moderate certainty).

• Second‐line systemic therapy for metastatic colorectal cancer 2017 · Cochrane Headline outcomes only
  RR 1.19 [1.01, 1.4]
  1 study · 279 participants
  Moderate

Group C cognitive behavioural therapy: cognitive behavioural therapy + supportive intervention vs non‐directive reflective listening + supportive intervention

• Interventions for prodromal stage of psychosis 2019 · Cochrane Headline outcomes only
  no estimate extracted
  0 studies · 0 participants
  GRADE not reported

Daily conventionally fractionated radiotherapy vs supportive care

• External beam radiation dose escalation for high grade glioma 2020 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 289 participants
  GRADE not reported

First‐line chemotherapy vs BSC

• Chemotherapy versus best supportive care for extensive small cell lung cancer 2013 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 65 participants
  Very low

Group C cognitive behavioural therapy: cognitive behavioural therapy + risperidone vs placebo or supportive treatment

It is very uncertain whether group C cognitive behavioural therapy: cognitive behavioural therapy… changes adverse effects: doctors' assessment of adverse effects UKU (events)… compared with supportive therapy + placebo (very low certainty).

• Interventions for prodromal stage of psychosis 2019 · Cochrane Headline outcomes only
  RR 1.43 [0.64, 3.16]
  1 study · 58 participants
  Very low

Group C cognitive behavioural therapy: cognitive behavioural therapy + placebo vs placebo or supportive treatment

It is very uncertain whether group C cognitive behavioural therapy: cognitive behavioural therapy… changes adverse effects: specific ‐ doctors' assessment of adverse effects… compared with supportive therapy + placebo (very low certainty).

• Interventions for prodromal stage of psychosis 2019 · Cochrane Headline outcomes only
  RR 1.39 [0.61, 3.18]
  1 study · 51 participants
  Very low

Intervention not reported

• Chemotherapy versus best supportive care for extensive small cell lung cancer 2013 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 542 participants
  Moderate

ACT subsidies combined with supportive interventions vs no subsidies

• Subsidising artemisinin‐based combination therapy in the private retail sector 2016 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 3 participants
  GRADE not reported