Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

21 questions · 21 findings · 9 reviews · Headline outcomes only

No studies found 10 · 47.6%GRADE not reported 1 · 4.8%Very low 5 · 23.8%Low 3 · 14.3%Moderate 2 · 9.5%High 0 · 0%

Selective serotonin reuptake inhibitors vs tricyclic antidepressants (TCAs)

Adverse effects during antidepressant treatment period (0‐12 weeks) · adults living with HIV and depression

It is very uncertain whether selective serotonin reuptake inhibitors (SSRI) changes adverse effects during antidepressant treatment period (0‐12 weeks) compared with tricyclic antidepressant (TCA) (very low certainty).

1 finding from 1 review

rTMS + pharmacotherapy vs sham rTMS + pharmacotherapy

Acceptability ‐ dropouts due to adverse effects · participants with panic disorder

It is very uncertain whether rTMS + pharmacotherapy changes acceptability: dropouts for adverse effects number of dropouts compared with sham rTMS + pharmacotherapy (very low certainty).

1 finding from 1 review

S‐adenosyl methionine as monotherapy vs tricyclic antidepressants (TCAs)

Acceptability. Participants experiencing troublesome adverse effects of any nature · depression in adults

S‐adenosyl methionine as monotherapy may leads to lower acceptability. Participants experiencing troublesome adverse effects… compared with tricyclic antidepressant agent (low certainty).

1 finding from 1 review