Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

33 questions · 33 findings · 11 reviews

No studies found 21 · 63.6%GRADE not reported 2 · 6.1%Very low 5 · 15.2%Low 3 · 9.1%Moderate 2 · 6.1%High 0 · 0%

Selective serotonin reuptake inhibitors vs tricyclic antidepressants (TCAs)

Adverse effects during antidepressant treatment period (0‐12 weeks) · adults living with HIV and depression

It is very uncertain whether selective serotonin reuptake inhibitors (SSRI) changes adverse effects during antidepressant treatment period (0‐12 weeks) compared with tricyclic antidepressant (TCA) (very low certainty).

1 finding from 1 review

Tongue scraper or tongue cleaner (One Drop Only tongue cleaner; Tongue-Putzer scraper; polystyrene scraper) vs Toothbrush (used to clean the tongue)

Adverse effects (tongue trauma, nausea) and acceptability · Adults (over 18 years) with a clinical or self-assessed diagnosis of halitosis
1 finding from 1 review
  • Tongue scraping for treating halitosis 2006 · Cochrane All outcomes
    1 week (Pedrazzi 2004)
    Pedrazzi 2004: six of ten (60%) participants complained of nausea and one participant of tongue trauma, only with the toothbrush; all participants were receptive to the tongue scraper. Seemann 2001: no adverse effects…
    2 studies
    GRADE not reported

rTMS + pharmacotherapy vs sham rTMS + pharmacotherapy

Acceptability ‐ dropouts due to adverse effects · participants with panic disorder

It is very uncertain whether rTMS + pharmacotherapy changes acceptability: dropouts for adverse effects number of dropouts compared with sham rTMS + pharmacotherapy (very low certainty).

1 finding from 1 review

S‐adenosyl methionine as monotherapy vs tricyclic antidepressants (TCAs)

Acceptability. Participants experiencing troublesome adverse effects of any nature · depression in adults

S‐adenosyl methionine as monotherapy may leads to lower acceptability. Participants experiencing troublesome adverse effects… compared with tricyclic antidepressant agent (low certainty).

1 finding from 1 review