What do systematic reviews say?

Oral plus nebulised antibiotics vs oral antibiotics plus nebulised placebo

Oral plus nebulised antibiotics showed no clear difference in adverse effects of treatment compared with oral antibiotics plus nebulised placebo (low certainty).

• Interventions for the eradication of meticillin‐resistant Staphylococcus aureus (MRSA) in people with cystic fibrosis 2022 · Cochrane Headline outcomes only
  OR 3 [0.11, 79.91]
  1 study · 29 participants
  Low

Oral vs topical antibiotics

• Antibiotics for trachoma 2019 · Cochrane Headline outcomes only
  no estimate extracted
  8 studies · 1583 participants
  Low

Oral ciprofloxacin and inhaled colistin vs inhaled tobramycin (TNS) plus oral ciprofloxacin

• Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 223 participants
  Moderate

Inhaled tobramycin (TNS) plus oral azithromycin vs TNS plus oral placebo

Inhaled tobramycin (TNS) plus oral azithromycin showed no clear difference in adverse effects of antibiotics: number of participants experiencing… compared with TNS plus oral placebo (moderate certainty).

• Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis 2023 · Cochrane Headline outcomes only
  RR 1.05 [0.96, 1.14]
  1 study · 221 participants
  Moderate

Oral ciprofloxacin and inhaled colistin vs no treatment

• Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 26 participants
  Very low

Oral ciprofloxacin and inhaled colistin vs inhaled tobramycin

It is very uncertain whether oral ciprofloxacin and inhaled colistin changes adverse effects of antibiotics: severe cough compared with inhaled tobramycin (TNS) (very low certainty).

• Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis 2023 · Cochrane Headline outcomes only
  OR 0.32 [0.01, 8.24]
  1 study · 58 participants
  Very low

Oral azithromycin vs control

• Antibiotics for trachoma 2019 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 3069 participants
  GRADE not reported

Oral azithromycin vs topical tetracycline

• Antibiotics for trachoma 2019 · Cochrane Headline outcomes only
  no estimate extracted
  3 studies · 6002 participants
  GRADE not reported

Intravenous ceftazidime with tobramycin vs ciprofloxacin

Intravenous ceftazidime with tobramycin probably leads to lower adverse effects of antibiotics: compared with oral ciprofloxacin (moderate certainty).

• Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis 2023 · Cochrane Headline outcomes only
  RR 0.97
  1 study · 285 participants
  Moderate

Acupuncture vs oral antibiotics plus warm compresses

The review found no eligible studies for this question.

• Acupuncture for acute hordeolum 2017 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found