Alginate dressing vs plain non‐adherent dressing
Adverse effects · people with venous leg ulcers
1 finding from 1 review
- no estimate extracted0 studies · 0 participantsGRADE not reported
Findings
What do systematic reviews say?
30 questions · 30 findings · 4 reviews
No studies found 2 · 6.7%GRADE not reported 27 · 90%Very low 1 · 3.3%Low 0 · 0%Moderate 0 · 0%High 0 · 0%
Alginate dressing vs alternative alginate dressing (Tegagen™ High Gelling)
Adverse effects · people with venous leg ulcers
1 finding from 1 review
- no estimate extracted0 studies · 0 participantsGRADE not reported
Levamisole (150 mg per day) vs placebo
Adverse effects · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…
1 finding from 1 review
- Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) 2012 · Cochrane All outcomesPatients receiving levamisole reported more adverse effects than those receiving placebo (mild stomach upset/nausea, diarrhoea, sleeplessness, dysgeusia/dysosmia), however no adverse effects were reported as requiring…8 studiesGRADE not reported
Sulodexide (heparin plus dermatan sulphate chains) vs placebo
Adverse effects · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…
1 finding from 1 review
- Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) 2012 · Cochrane All outcomesSulodexide was not associated with significant adverse events.1 study · 20 participantsGRADE not reported
Rofecoxib (oral, 50 mg on first day then 25 to 50 mg per day for 4 days) vs Tinidazole (1 g per day for 3 days)
Adverse effects · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…
1 finding from 1 review
- Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) 2012 · Cochrane All outcomes4 daysNo adverse effects reported in translation.1 study · 60 participantsGRADE not reported
Beta-glucan (1.3/1.6 beta-glucan 10 mg twice daily for 20 days) vs placebo
Adverse effects · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…
1 finding from 1 review
- Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) 2012 · Cochrane All outcomes20 daysThere was no reporting of adverse effects.1 study · 31 participantsGRADE not reported
Levamisole 50 mg three times per day for days 1 and 2 vs Levamisole 50 mg three times per day for day 1 and placebo for day 2 (lower dose)
Adverse effects · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…
1 finding from 1 review
- Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) 2012 · Cochrane All outcomes16 weeksTwo patients in each group reported unwanted effects.1 studyGRADE not reported
LongoVital (herbal plus vitamin component) vs placebo
Adverse effects · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…
1 finding from 1 review
- Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) 2012 · Cochrane All outcomes4 monthsReported adverse events were minor and evenly distributed between the groups.1 study · 40 participantsGRADE not reported
Prednisone (oral, commencing 25 mg with phased dose reduction over 2 months) vs placebo
Adverse effects · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…
1 finding from 1 review
- Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) 2012 · Cochrane All outcomes2 monthsFemiano 2003: one significant adverse event (gastritis) for the prednisone group versus none for placebo. Femiano 2010: more drug-related adverse effects for those treated with prednisone than placebo.2 studiesGRADE not reported
Vitamin B12 (sublingual, 1000 mcg daily for 6 months) vs placebo
Adverse effects · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…
1 finding from 1 review
- Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) 2012 · Cochrane All outcomes6 monthsNo adverse events were associated with receiving vitamin B12 or placebo in this study.1 study · 58 participantsGRADE not reported
Sulodexide (heparin plus dermatan sulphate chains) vs prednisone
Adverse effects · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…
1 finding from 1 review
- Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) 2012 · Cochrane All outcomesSulodexide was without significant adverse events; one significant adverse event (gastritis) was reported for the prednisone group.1 study · 20 participantsGRADE not reported
Bee propolis (one 500 mg capsule per day) vs placebo
Adverse effects · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…
1 finding from 1 review
- Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) 2012 · Cochrane All outcomes6 months (minimum)Propolis was associated with low rates of minimal side effects.1 study · 19 participantsGRADE not reported
Subantimicrobial dose doxycycline (20 mg twice daily for 90 days) vs placebo
Adverse effects · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…
1 finding from 1 review
- Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) 2012 · Cochrane All outcomes90 daysNo differences in adverse events were reported.1 study · 50 participantsGRADE not reported
Individualised homeopathic medicine (two doses over 24 hours) vs placebo
Adverse effects · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…
1 finding from 1 review
- Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) 2012 · Cochrane All outcomes6 daysNo participant needed to discontinue treatment due to adverse events.1 study · 100 participantsGRADE not reported
Colchicine (0.5 mg three times per day) vs Clofazimine (100 mg daily for 30 days, then 100 mg every other day)
Adverse effects · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…
1 finding from 1 review
- Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) 2012 · Cochrane All outcomes6 monthsClofazimine was associated with an increase in cutaneous adverse effects (Fisher's exact test P=0.015), easily controlled; there was a greater percentage of treatment interruptions in the colchicine group due to…1 study · 46 participantsGRADE not reported
Leukotriene receptor antagonist vs placebo
Adverse effects · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…
1 finding from 1 review
- Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) 2012 · Cochrane All outcomes2 monthsThe study reported equal drug-related adverse effects for those treated with montelukast and placebo.1 study · 40 participantsGRADE not reported
Clofazimine (100 mg daily for 30 days, then 100 mg every other day) vs placebo
Adverse effects · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…
1 finding from 1 review
- Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) 2012 · Cochrane All outcomes6 monthsClofazimine was associated with an increase in cutaneous adverse effects (skin pigmentation and drying) (Fisher's exact test P=0.015), but these were reported to be easily controlled.1 study · 43 participantsGRADE not reported
Perilla cooking oil vs Soybean cooking oil
Adverse effects · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…
1 finding from 1 review
- Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) 2012 · Cochrane All outcomes8 monthsNo adverse events were reported.1 study · 33 participantsGRADE not reported
Pentoxifylline vs placebo
Adverse effects · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…
1 finding from 1 review
- Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) 2012 · Cochrane All outcomes60 days (plus 60-day follow-up)Patients receiving pentoxifylline reported more adverse events than those in the placebo group but this was not statistically significant (69% reported adverse effects: dizziness, headaches, stomach upset, increased…1 study · 26 participantsGRADE not reported
Colchicine (0.5 mg per day for 3 months) vs prednisolone
Adverse effects · Participants with a previous or current history of recurrent aphthous stomatitis (RAS), diagnosed on history and clinical examination;…
1 finding from 1 review
- Systemic interventions for recurrent aphthous stomatitis (mouth ulcers) 2012 · Cochrane All outcomes3 monthsColchicine was associated with statistically significantly more adverse effects than prednisolone (nine participants reporting adverse effects on colchicine versus two on prednisolone).1 study · 34 participantsGRADE not reported