What do systematic reviews say?

Topical corticosteroids vs Another topical agent or placebo

The review found no eligible studies for this question.

• Topical treatments for HIV‐related oral ulcers 2012 · Cochrane All outcomes
  No studies were included in this review. A total of 233 abstracts were retrieved; 25 were selected as potentially eligible but all were excluded (10 reported systemic rather than topical treatment; 3 non‐RCTs; 6…
  0 studies
  No studies found

Topical thalidomide vs Another topical agent or placebo

The review found no eligible studies for this question.

• Topical treatments for HIV‐related oral ulcers 2012 · Cochrane All outcomes
  No studies were included in this review. A total of 233 abstracts were retrieved; 25 were selected as potentially eligible but all were excluded (10 reported systemic rather than topical treatment; 3 non‐RCTs; 6…
  0 studies
  No studies found

Antiseptic mouthwash (e.g. chlorhexidine) vs Another topical agent or placebo

The review found no eligible studies for this question.

• Topical treatments for HIV‐related oral ulcers 2012 · Cochrane All outcomes
  No studies were included in this review. A total of 233 abstracts were retrieved; 25 were selected as potentially eligible but all were excluded (10 reported systemic rather than topical treatment; 3 non‐RCTs; 6…
  0 studies
  No studies found

HAART regimen + topical treatment vs HAART alone

The review found no eligible studies for this question.

• Topical treatments for HIV‐related oral ulcers 2012 · Cochrane All outcomes
  No studies were included in this review. A total of 233 abstracts were retrieved; 25 were selected as potentially eligible but all were excluded (10 reported systemic rather than topical treatment; 3 non‐RCTs; 6…
  0 studies
  No studies found

Intraoral distalising appliance vs Headgear (extraoral appliance)

The review found no eligible studies for this question.

• Orthodontic treatment for distalising upper first molars in children and adolescents 2013 · Cochrane All outcomes
  Adverse effects were not reported by these studies.
  0 studies
  No studies found

Intraoral distalising appliance vs Another (different) intraoral distalising appliance

The review found no eligible studies for this question.

• Orthodontic treatment for distalising upper first molars in children and adolescents 2013 · Cochrane All outcomes
  Adverse effects were not reported by these studies.
  0 studies
  No studies found

Orthodontic distalising appliance (intraoral or extraoral) vs no intervention

The review found no eligible studies for this question.

• Orthodontic treatment for distalising upper first molars in children and adolescents 2013 · Cochrane All outcomes
  Adverse effects were not reported in the studies of this comparison; no included study across the review reported adverse effects, harm or injury.
  0 studies
  No studies found

Topical fluoride therapy (toothpaste, mouthrinse, gel or varnish; any fluoride agent/concentration; frequency at least once a year) vs placebo or no treatment

• Topical fluoride (toothpastes, mouthrinses, gels or varnishes) for preventing dental caries in children and adolescents 2003 · Cochrane All outcomes
  Data on adverse effects (stain score, proportion of children with tooth staining, signs of sensitivity in oral soft tissue, adverse symptoms such as nausea/vomiting, etching of enamel) were reported in only a few…
  Studies not reported
  GRADE not reported

Double primary (canine and first molar) tooth extraction vs Single primary (canine) tooth extraction

The review found no eligible studies for this question.

• Interventions for promoting the eruption of palatally displaced permanent canine teeth, without the need for surgical… 2021 · Cochrane All outcomes
  The studies did not report adverse events.
  0 studies
  No studies found

Extraction of the primary (baby) canine (single primary tooth extraction) vs No extraction (non-intervention control)

The review found no eligible studies for this question.

• Interventions for promoting the eruption of palatally displaced permanent canine teeth, without the need for surgical… 2021 · Cochrane All outcomes
  Only root resorption was assessed; other adverse effects (gingival disease, demineralisation) were not reported.
  0 studies
  No studies found

Flossing plus toothbrushing (self-performed; manual or automated floss) vs Toothbrushing alone

• Flossing for the management of periodontal diseases and dental caries in adults 2011 · Cochrane All outcomes
  Not estimable (5 studies). Adverse effects were assessed in five studies, but they used different outcome measures, so meta-analysis was not appropriate. The main harm identified was soft-tissue trauma to the gingival…
  5 studies
  GRADE not reported

Facemask with rapid maxillary expansion (RME) vs Pushing Splints

• Orthodontic treatment for prominent lower front teeth (Class III malocclusion) in children 2024 · Cochrane All outcomes

  End of treatment
  Galeotti 2021: occasional skin irritation on the chin and three appliance breakages (one facemask, two Pushing Splints).
  1 study · 42 participants
  GRADE not reported

Resin-based fissure sealant (2nd/3rd/4th generation) vs No sealant (control/no treatment)

• Pit and fissure sealants for preventing dental decay in permanent teeth 2017 · Cochrane All outcomes
  Two trials measured adverse effects. None were reported.
  2 studies
  GRADE not reported

Glass ionomer-based sealant vs No sealant (control/no treatment)

The review found no eligible studies for this question.

• Pit and fissure sealants for preventing dental decay in permanent teeth 2017 · Cochrane All outcomes
  Adverse effects not measured.
  Studies not reported
  No studies found

Glass ionomer-based sealant vs Resin-based sealant

• Pit and fissure sealants for preventing dental decay in permanent teeth 2017 · Cochrane All outcomes
  One trial measured adverse effects. None reported.
  1 study
  GRADE not reported

Hyperbaric oxygen therapy plus standard care (surgery, antibiotics, oral rinse) vs Standard care alone (surgery, antibiotics, oral rinse)

The review found no eligible studies for this question.

• Interventions for treating bisphosphonate‐related osteonecrosis of the jaw (BRONJ) 2016 · Cochrane All outcomes
  no estimate extracted
  0 studies
  No studies found

Sodium hypochlorite 1.3% with MTAD final rinse vs Sodium hypochlorite 1.3% with normal saline final rinse

The review found no eligible studies for this question.

• Irrigants for non‐surgical root canal treatment in mature permanent teeth 2012 · Cochrane All outcomes
  no estimate extracted
  0 studies
  No studies found

Sodium hypochlorite 5.25% with EDTA 17% vs Sodium hypochlorite 1.3% with MTAD

The review found no eligible studies for this question.

• Irrigants for non‐surgical root canal treatment in mature permanent teeth 2012 · Cochrane All outcomes
  no estimate extracted
  0 studies
  No studies found

Sodium hypochlorite 5.25% vs Sodium hypochlorite 5.25% with hydrogen peroxide 3%

The review found no eligible studies for this question.

• Irrigants for non‐surgical root canal treatment in mature permanent teeth 2012 · Cochrane All outcomes
  no estimate extracted
  0 studies
  No studies found

Sodium hypochlorite 5.25% with hydrogen peroxide 3% vs Normal saline

The review found no eligible studies for this question.

• Irrigants for non‐surgical root canal treatment in mature permanent teeth 2012 · Cochrane All outcomes
  no estimate extracted
  0 studies
  No studies found