What do systematic reviews say?

Antioxidants (lycopene, curcumin, Oxitard) vs Placebo or no active treatment

• Interventions for managing oral submucous fibrosis 2024 · Cochrane All outcomes
  Adverse effects (any): 0 in placebo vs 2 minor (flatulence and bloating); 90 (1); no GRADE rating given.
  1 study · 90 participants
  GRADE not reported

Vasodilator vs Placebo or no active treatment

• Interventions for managing oral submucous fibrosis 2024 · Cochrane All outcomes
  Adverse effects (any): 0 placebo vs 14 minor (transient flushing and upper trunk warmness); 85 (2); no GRADE rating.
  2 studies · 85 participants
  GRADE not reported

Periodontal treatment (subgingival instrumentation, with or without antimicrobials/surgery) vs usual care or no treatment

• Treatment of periodontitis for glycaemic control in people with diabetes mellitus 2022 · Cochrane All outcomes

  3-4 months
  SoF comment: insufficient evidence to determine whether SRP for glycaemic control is associated with any harms; most studies did not evaluate adverse effects. Where reported (e.g. D'Aiuto 2018) serious adverse events…
  Studies not reported
  GRADE not reported

Silver diamine fluoride (SDF) vs Other methods (pooled: ART/glass ionomer cement, nano-silver fluoride, sodium fluoride varnish, placebo)

SDF commonly causes black staining of arrested lesions; only mild, transient adverse events were reported, with no major adverse events (ungraded).

• The role of silver diamine fluoride as dental caries preventive and arresting agent: a systematic review and… 2024 All outcomes

  up to 30 months · Children/adults with dental caries; multiple countries; community/clinic care setting not clearly specified
  Black staining of arrested lesions reported in most studies; 4 studies reported mild transient events (gingival blenching/pain; diarrhea/stomachache; burning, bad taste, pain, mouth injury, dissatisfaction with…
  Studies not reported
  GRADE not reported

Any intervention to manage relapse: fixed options (labial braces, lingual braces, fixed lingual wire) or removable options (Hawley's retainer with spring elastomeric module, Bloore removable aligner, other Hawley's retainer modifications, Invisalign, Clearstep) vs no intervention or another intervention

The review found no eligible studies for this question.

• Interventions for managing relapse of the lower front teeth after orthodontic treatment 2013 · Cochrane All outcomes
  No RCTs met the inclusion criteria for this review. After deduplication, the electronic searching identified 527 publications; after reviewing the titles and abstracts, none focused on interventions to correct the…
  0 studies
  No studies found