Findings

What do systematic reviews say?

3 questions · 3 findings · 2 reviews · Oral Health

No studies found 0 · 0%GRADE not reported 1 · 33.3%Very low 1 · 33.3%Low 1 · 33.3%Moderate 0 · 0%High 0 · 0%

Adverse effects of toothpaste · Children and adolescents with immature permanent dentition (aged 5 to 16 years at study start)

1 finding from 1 review

Fluoride toothpastes of different concentrations for preventing dental caries 2019 · Cochrane All outcomes
Closest to 36 months
16 studies assessed possible side effects, principally oral (soft tissue) pathologies and tooth staining. 6 studies reported no untoward events; 6 reported greater staining in the stannous fluoride group; 1 reported no…
16 studies
GRADE not reported

Adverse effects · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment

Topical triamcinolone acetonide may leads to lower adverse effects compared with topical tacrolimus (low certainty).

1 finding from 1 review

Interventions for treating oral lichen planus: corticosteroid therapies 2020 · Cochrane All outcomes
3-8 weeks
RR 0.47 [0.22, 0.99]
2 studies · 58 participants
Low

Adverse effects · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment

It is very uncertain whether topical clobetasol propionate changes adverse effects compared with topical tacrolimus (very low certainty).

1 finding from 1 review

Interventions for treating oral lichen planus: corticosteroid therapies 2020 · Cochrane All outcomes
3-8 weeks
RR 0.05 [0.00, 0.83]
2 studies · 100 participants
Very low