Findings

What do systematic reviews say?

Refine by population, intervention, comparison or outcome
More filters
Evidence found and GRADE certainty

377 questions · 402 findings · 108 reviews

No studies found 114 · 28.4%GRADE not reported 107 · 26.6%Very low 88 · 21.9%Low 41 · 10.2%Moderate 45 · 11.2%High 7 · 1.7%

Dietary supplements (alpha lipoic acid +/- adjunctive ingredients) vs placebo

Adverse effects: intermittent facial skin rash · People with primary burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such symptoms

It is very uncertain whether dietary supplements (alpha lipoic acid +/- adjunctive ingredients) changes adverse effects: intermittent facial skin rash compared with placebo (very low certainty).

1 finding from 1 review

Anticonvulsants (gabapentin 300 mg/day) vs placebo

Adverse effects: drowsiness (gabapentin alone) · People with primary burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such symptoms

It is very uncertain whether anticonvulsants (gabapentin 300 mg/day) changes adverse effects: drowsiness (gabapentin alone) compared with placebo (very low certainty).

1 finding from 1 review

Chemotherapy (any regimen; added to, or compared with, locoregional treatment) vs Locoregional treatment and/or an alternative chemotherapy regimen

Toxicity / adverse effects (harms) of chemotherapy · People receiving curative-intent treatment for oral cavity and oropharyngeal (squamous cell) cancer
1 finding from 1 review

Abdominal dermal fat graft vs Nasolabial flap

Adverse effects · People of any age with a confirmed diagnosis, by clinical examination and biopsy, of oral submucous fibrosis (OSF)
1 finding from 1 review
  • Kania 2022 reported 3/30 serious adverse effects (graft failure) requiring prolonged hospital stay in the abdominal dermal fat graft group; no GRADE rating.
    1 study · 30 participants
    GRADE not reported

Topical triamcinolone acetonide vs pimecrolimus 1%

Adverse effects · People with symptomatic, biopsy-confirmed oral lichen planus (OLP); not concurrently receiving other OLP treatment

Topical triamcinolone acetonide showed no clear difference in adverse effects compared with topical pimecrolimus; GRADE not reported.

1 finding from 1 review