Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

403 questions · 428 findings · 117 reviews

No studies found 135 · 31.5%GRADE not reported 107 · 25%Very low 90 · 21%Low 44 · 10.3%Moderate 45 · 10.5%High 7 · 1.6%

Keratinocyte growth factor (KGF; palifermin or repifermin), intravenous vs placebo

Adverse effects · Patients receiving radiotherapy on its own or in addition to chemotherapy to the head and neck region
1 finding from 1 review

Amifostine (intravenous) vs Amifostine (subcutaneous)

Adverse effects · Patients receiving radiotherapy on its own or in addition to chemotherapy to the head and neck region
1 finding from 1 review

Targeted mass media intervention vs targeted mass media intervention plus personalised content

Adverse effects · adult, ethnic minority groups: Latino immigrants, elderly Chinese immigrants, self‐described Americans of African heritage

The review found no eligible studies for this question.

1 finding from 1 review

Topical treatments (benzydamine hydrochloride oral rinse) vs placebo

Adverse effects · People with primary burning mouth syndrome (BMS), that is, oral mucosal pain with no dental or medical cause for such symptoms
1 finding from 1 review
  • Interventions for treating burning mouth syndrome 2016 · Cochrane All outcomes
    short-term (up to 3 months) · benzydamine hydrochloride
    SoF9. Adverse effects: single study narratively reported that no adverse effects occurred from benzydamine hydrochloride oral rinse; 20 participants (1 RCT); very low.
    1 study · 20 participants
    Very low

Hyperbaric oxygen therapy plus standard care (surgery, antibiotics, oral rinse) vs Standard care alone (surgery, antibiotics, oral rinse)

Adverse effects · People with BRONJ (mean age ~66 years; most treated with bisphosphonates for cancer (multiple myeloma, breast cancer) or osteoporosis)

The review found no eligible studies for this question.

1 finding from 1 review