What do systematic reviews say?

Therapeutic contact lens vs topical lubrication

• Interventions for recurrent corneal erosions 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  Very low

Intervention not reported

The review found no eligible studies for this question.

• Graduated compression stockings for prevention of deep vein thrombosis 2018 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Maxillary distraction osteogenesis vs Orthognathic surgery (conventional Le Fort I osteotomy)

• Maxillary distraction osteogenesis versus orthognathic surgery for cleft lip and palate patients 2018 · Cochrane All outcomes

  12 months
  SoF (Very Low): Clinical morbidities assessed with questionnaires, follow-up 12 months; risk with orthognathic surgery 3/14; risk with maxillary distraction osteogenesis 3/15; relative effect -; 29 participants (1…
  1 study · 29 participants
  Very low

Intervention not reported

• Aspiration of the elbow joint for treating radial head fractures 2014 · Cochrane Headline outcomes only
  no estimate extracted
  2 studies · 108 participants
  GRADE not reported

Intervention not reported

• Aspiration of the elbow joint for treating radial head fractures 2014 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 80 participants
  GRADE not reported

Light vibrational forces (LVF) vs Conventional orthodontic appliance treatment

• Non‐surgical adjunctive interventions for accelerating tooth movement in patients undergoing orthodontic treatment 2023 · Cochrane All outcomes
  No serious adverse effects were reported across five studies that assessed harms (Katchooi 2018; Lombardo 2018; Pavlin 2015; Reiss 2020; Taha 2020).
  5 studies
  GRADE not reported

Injectional interferon alpha‐2B vs Normal saline

The review found no eligible studies for this question.

• Non‐surgical therapies for Peyronie's disease 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Injectional nicardipine vs Normal saline

It is very uncertain whether injectional nicardipine changes treatment‐related adverse effects compared with saline (very low certainty).

• Non‐surgical therapies for Peyronie's disease 2023 · Cochrane Headline outcomes only
  RR 2.82 [0.12, 66.62]
  1 study · 62 participants
  Very low

Injectional collagenase vs placebo

The review found no eligible studies for this question.

• Non‐surgical therapies for Peyronie's disease 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found
• Non‐surgical therapies for Peyronie's disease 2023 · Cochrane Headline outcomes only
  RR 2.32 [1.98, 2.72]
  1 study · 832 participants
  Moderate

Potassium paraaminobenzoate vs placebo

It is very uncertain whether potassium paraaminobenzoate changes treatment‐related adverse effects compared with placebo (very low certainty).

• Non‐surgical therapies for Peyronie's disease 2023 · Cochrane Headline outcomes only
  RR 1.27 [0.36, 4.48]
  1 study · 103 participants
  Very low

Injectional verapamil vs saline (short‐term)

• Non‐surgical therapies for Peyronie's disease 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 14 participants
  Very low

Injectional Botox vs placebo

The review found no eligible studies for this question.

• Non‐surgical therapies for Peyronie's disease 2023 · Cochrane Headline outcomes only
  no estimate extracted
  Studies not reported
  No studies found

Extracorporeal shockwave therapy vs sham

It is very uncertain whether extracorporeal shock wave treatment (ESWT) changes treatment‐related adverse effects compared with sham (very low certainty).

• Non‐surgical therapies for Peyronie's disease 2023 · Cochrane Headline outcomes only
  RR 2.73 [0.74, 10.14]
  3 studies · 166 participants
  Very low

Penile traction therapy vs no treatment (short‐term)

• Non‐surgical therapies for Peyronie's disease 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 90 participants
  Very low

Laxative plus bulking agent vs laxative alone

It is very uncertain whether laxative plus bulking agent changes adverse effects on women: faecal incontinence during first 10… compared with laxative alone (very low certainty).

• Interventions for preventing postpartum constipation 2020 · Cochrane Headline outcomes only
  RR 1.81 [1.01, 3.23]
  1 study · 147 participants
  Very low

Triangular flap vs Envelope flap

Triangular flap led to lower adverse effects (wound dehiscence) compared with envelope flap; GRADE not reported.

• Surgical techniques for the removal of mandibular wisdom teeth 2020 · Cochrane All outcomes

  up to 30 days
  no estimate extracted
  2 studies · 39 participants
  GRADE not reported

Primary (complete) wound closure vs Secondary (partial) wound closure

It is very uncertain whether primary (complete) wound closure changes adverse effects (reactionary bleeding) compared with secondary (partial) wound closure (very low certainty).

• Surgical techniques for the removal of mandibular wisdom teeth 2020 · Cochrane All outcomes

  up to 30 days
  RR 0.41 [0.11, 1.47]
  1 study · 82 participants
  Very low

Lingual nerve retractor (subperiosteal or Free's) vs No retractor

The review found no eligible studies for this question.

• Surgical techniques for the removal of mandibular wisdom teeth 2020 · Cochrane All outcomes

  up to 30 days
  no estimate extracted
  Studies not reported
  No studies found

Coronectomy vs Complete extraction (odontectomy)

The review found no eligible studies for this question.

• Surgical techniques for the removal of mandibular wisdom teeth 2020 · Cochrane All outcomes

  up to 30 days
  no estimate extracted
  Studies not reported
  No studies found

Injectional betamethasone vs Normal saline

• Non‐surgical therapies for Peyronie's disease 2023 · Cochrane Headline outcomes only
  no estimate extracted
  1 study · 30 participants
  Very low