Findings

What do systematic reviews say?

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Evidence found and GRADE certainty

95 questions · 95 findings · 47 reviews

No studies found 25 · 26.3%GRADE not reported 11 · 11.6%Very low 22 · 23.2%Low 21 · 22.1%Moderate 10 · 10.5%High 6 · 6.3%

Rice fortified with iron alone or in combination with other micronutrients vs unfortified rice (no micronutrients added)

Any adverse effects (hookworm infection risk) · general population of all age groups (including pregnant women) from any country, over two years of age

Rice fortified with iron alone or in combination with other… may leads to higher any adverse effects (hookworm infection risk) compared with unfortified rice (no micronutrients added) (low certainty).

1 finding from 1 review

Triclosan/copolymer-containing fluoride toothpaste vs Fluoride toothpaste without triclosan

Tooth staining/discolouration (adverse effect) · Children and adults (aged 16 years or less = children, over 16 = adults) without periodontitis at baseline; in practice mostly adults,…

Triclosan/copolymer-containing fluoride toothpaste showed no clear difference in adverse effects (tooth staining, Meckel Stain Score, 6 months) compared with fluoride toothpaste without triclosan; GRADE not reported.

1 finding from 1 review

Pericyazine vs atypical antipsychotics

Adverse effects: any observed extrapyramidal symptoms ‐ short term (up to 6 months) · patients with schizophrenia

It is very uncertain whether pericyazine changes adverse Effects ‐ Extrapyramidal symptoms compared with atypical antipsychotic (very low certainty).

1 finding from 1 review

Electrical counter-stimulation device (DentalVibe) vs Conventional treatment (no stimulation)

Adverse effects · Children and adolescents having dental treatment under local anaesthetic without general anaesthesia

The review found no eligible studies for this question.

1 finding from 1 review

Hyperbaric oxygen therapy (HBO) following extractions vs penicillin G

Adverse effects · Adults with head and neck cancer undergoing curative or adjuvant radiotherapy (at risk of osteoradionecrosis of the jaws)
1 finding from 1 review

Transcutaneous electrical nerve stimulation (TENS) and standard urotherapy vs pelvic floor muscle training (PFMT) with electromyographic biofeedback and standard urotherapy

Adverse effects · children aged 5 to 16 years with daytime urinary incontinence

The review found no eligible studies for this question.

1 finding from 1 review