What do systematic reviews say?

BENZODIAZEPINES AS SOLE TREATMENT vs placebo

• Benzodiazepines for schizophrenia 2012 · Cochrane Headline outcomes only
  no estimate extracted
  4 studies · 161 participants
  Very low

ADJUNCTIVE BENZODIAZEPINES + ANTIPSYCHOTICS vs placebo/no adjunctive treatment + antipsychotics

It is very uncertain whether ADJUNCTIVE BENZODIAZEPINES + ANTIPSYCHOTICS changes leaving the study early due to adverse effects (overall tolerability… compared with PLACEBO/NO ADJUNCTIVE TREATMENT + ANTIPSYCHOTICS (very low certainty).

• Benzodiazepines for schizophrenia 2012 · Cochrane Headline outcomes only
  RR 3.24 [0.68, 15.45]
  6 studies · 415 participants
  Very low

VIDEO GAMES (COMMERCIAL NON‐EXERGAMES) (plus standard care) vs COGNITIVE REMEDIATION (plus standard care)

VIDEO GAMES (COMMERCIAL NON‐EXERGAMES) (plus standard care) showed no clear difference in adverse effects*: leaving the study early ‐ did not leave ‐ by end… compared with COGNITIVE REMEDIATION (plus standard care) (low certainty).

• Video games for people with schizophrenia 2021 · Cochrane Headline outcomes only
  RR 0.96 [0.87, 1.06]
  5 studies · 395 participants
  Low

Benzodiazepines vs antipsychotics

It is very uncertain whether BENZODIAZEPINES changes leaving the study early due to adverse effects (overall tolerability… compared with ANTIPSYCHOTICS (very low certainty).

• Benzodiazepines for schizophrenia 2012 · Cochrane Headline outcomes only
  RR 13 [0.78, 216.39]
  5 studies · 444 participants
  Very low

TEMPOROPARIETAL TMS vs usual care

It is very uncertain whether TEMPOROPARIETAL TMS changes adverse effects: Leaving the study early compared with STANDARD TREATMENT (very low certainty).

• Transcranial magnetic stimulation (TMS) for schizophrenia 2015 · Cochrane Headline outcomes only
  RR 0.33 [0.08, 1.46]
  2 studies · 140 participants
  Very low