Findings

What do systematic reviews say?

2 questions · 2 findings · 1 reviews · Epilepsy

No studies found 0 · 0%GRADE not reported 0 · 0%Very low 0 · 0%Low 0 · 0%Moderate 1 · 50%High 1 · 50%

50% or greater reduction in seizure frequency Number of seizures · patients with drug‐resistant epilepsy

Flunarizine showed no clear difference in 50% or greater reduction in seizure frequency Number of seizures compared with placebo (high certainty).

1 finding from 1 review

Calcium antagonists as an add‐on therapy for drug‐resistant epilepsy 2013 · Cochrane Headline outcomes only
RR 1.53 [0.59, 3.96]
1 study · 93 participants
High

50% or greater reduction in seizure frequency Number of seizures · patients with drug‐resistant epilepsy

Nimodipine showed no clear difference in 50% or greater reduction in seizure frequency Number of seizures compared with placebo (moderate certainty).

1 finding from 1 review

Calcium antagonists as an add‐on therapy for drug‐resistant epilepsy 2013 · Cochrane Headline outcomes only
RR 7.78 [0.46, 130.88]
1 study · 17 participants
Moderate