Nimodipine vs placebo: 50% or greater reduction in seizure frequency Number of seizures
Nimodipine showed no clear difference in 50% or greater reduction in seizure frequency Number of seizures compared with placebo (moderate certainty).
What each review found
Include earlier review versions| Finding | Effect | Studies | GRADE certainty |
|---|---|---|---|
Nimodipine vs placebo 50% or greater reduction in seizure frequency Number of seizures · patients with drug‐resistant epilepsy Nimodipine showed no clear difference in 50% or greater reduction in seizure frequency Number of seizures compared with placebo (moderate certainty). Calcium antagonists as an add‐on therapy for drug‐resistant epilepsy (2013) · Cochrane Headline outcomes only | RR 7.78 [0.46, 130.88] | 1 study · 17 participants | Moderate |
Findings are shown side by side, never pooled across reviews.
The reviews
| Review | Searched up to | Included studies | AMSTAR 2 |
|---|---|---|---|
| Calcium antagonists as an add‐on therapy for drug‐resistant epilepsy 2013 · Cochrane Headline outcomes only | Not reported | list not extracted yet | Not assessed |
Studies behind the findings
None of these reviews ties its included studies to this outcome in the data here. Cochrane reviews and reviews with headline outcomes only do not list their studies yet.
How reviews are matched to this question
Reviews word the same question differently. Four decision models (TypeSafe's Jev, Liquid AI's d1-ultra, SubQ Snap and Baseten's Elephant) judged each wording of the population, intervention, comparator and outcome against the others; two wordings count as the same when at least three of them agree and none clearly disagrees, and findings count as this question only when all four elements match. Timing, setting and subgroup never split a question: they are shown on each finding.